SAB4200180

Anti-Cullin 3 antibody ,Mouse monoclonal

clone CUL3-9, purified from hybridoma cell culture

• Sinónimos: Anti-CUL3
• Número MDL: MFCD03454920
• Código UNSPSC: 12352203
• NACRES: NA.41

Propiedades

• origen biológico: mouse
• conjugado: unconjugated
• forma del anticuerpo: purified from hybridoma cell culture
• tipo de anticuerpo: primary antibodies
• clon: CUL3-9, monoclonal
• Formulario: buffered aqueous solution
• mol peso: antigen 80 kDa
• reactividad de especies: rat, human, mouse
• concentración: ~1.0 mg/mL
• técnicas: immunoprecipitation (IP): suitable; western blot: 0.5-1.0 μg/mL using whole extracts of human Jurkat cells or mouse brain.
• isotipo: IgG1
• Nº de acceso UniProt: Q13618
• Condiciones de envío: dry ice
• temp. de almacenamiento: −20°C
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: human ... CUL3(8452) ; mouse ... Cul3(26554) ; rat ... Cul3(301555)

Descripción

Descripción general

Cullin 3 (CUL3) is a member of cullin protein family and is encoded by the gene mapped to human chromosome 2q36.2. The encoded protein is a core component of cullin/RING E3 ubiquitin ligase (CRL) and is ubiquitously expressed. The protein is characterized with a cullin homology domain.

Monoclonal Anti-Cullin 3 (mouse IgG1 isotype) is derived from the hybridoma CUL3-9 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a synthetic peptide of human Cullin 3.

Aplicación

Monoclonal Anti-Cullin 3 antibody produced in mouse has been used in western blotting and immunoprecipitation.

Acciones bioquímicas o fisiológicas

Cullin 3 (CUL3) acts as a scaffold protein and facilitates the organization of a large number of ubiquitin ligase complexes. It plays a vital role in the regulation of electrolyte homeostasis and blood pressure. The encoded protein acts as a key factor in protein ubiquitination and is also implicated in early embryonic development. One important role of CUL3 is to promote invasion and migration of trophoblast cells. Mutation in the gene leads to onset of pre-eclampsia and pseudohypoaldosteronism type II.

Forma física

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable