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Documentos clave

SAB3500576

Sigma-Aldrich

Anti-MFSD2A antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Sinónimos:

Mfsd2A Antibody, Mfsd2A Antibody - Anti-MFSD2A antibody produced in rabbit, Anti-Major facilitator superfamily domain-containing protein 2A, Anti-mfsd2aa

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About This Item

Código UNSPSC:
12352203
NACRES:
NA.41

origen biológico

rabbit

conjugado

unconjugated

forma del anticuerpo

affinity isolated antibody

tipo de anticuerpo

primary antibodies

clon

polyclonal

Formulario

buffered aqueous solution

reactividad de especies

mouse, rat, human

técnicas

immunofluorescence: suitable
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable

Nº de acceso NCBI

NP_001007452

Nº de acceso UniProt

Q5U3U7

Condiciones de envío

dry ice

temp. de almacenamiento

−20°C

modificación del objetivo postraduccional

unmodified

Información sobre el gen

zebrafish ... mfsd2aa(492810)

Descripción general

Major facilitator superfamily domain containing 2a (Mfsd2a)is a sodium-dependent lysophosphatidylcholine (LPC) transporter. The endothelium of the micro vessels in blood brain barrier express high levels of Mfsd2a.

Inmunógeno

MFSD2A antibody was raised against an 18 amino acid peptide near the carboxy terminus of human MFSD2A.

Acciones bioquímicas o fisiológicas

Major facilitator superfamily domain containing 2a (Mfsd2a) acts as a transporter for the essential omega-3 fatty acid docosahexaenoic acid. It is essential at the blood-brain barrier for postnatal brain growth. A leaky blood-brain barrier from embryonic stages through to adulthood is observed if there is a genetic variation in this gene. Mutation in MFSD2A gene results in microcephaly and ventriculomegaly.

Características y beneficios

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Ligadura / enlace

The action of this antibody can be blocked using blocking peptide SBP3500576.

Forma física

Supplied in PBS with 0.02% sodium azide.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Referencia del producto
Descripción
Precios

SBP3500576

MFSD2A Blocking Peptide for SAB3500576

Código de clase de almacenamiento

10 - Combustible liquids

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number
60251603
60251004

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Inactivating Mutations in MFSD2A, Required for Omega-3 Fatty Acid Transport in Brain, Cause a Lethal Microcephaly Syndrome
Guemez-GA, et al.
Nature Genetics, 47(7), 809-809 (2015)
Mfsd2a is critical for the formation and function of the blood-brain barrier
Ben-ZA, et al.
Nature, 507-511 (2014)
The lysolipid transporter Mfsd2a regulates lipogenesis in the developing brain
Chan JP, et al.
PLoS Biology, 16(8), e2006443-e2006443 (2018)
Takuro Iwao et al.
PloS one, 18(2), e0281946-e0281946 (2023-02-17)
Nutrients are actively taken up by the brain via various transporters at the blood-brain barrier (BBB). A lack of specific nutrients in the aged brain, including decreased levels of docosahexaenoic acid (DHA), is associated with memory and cognitive dysfunction. To
Long N Nguyen et al.
Nature, 509(7501), 503-506 (2014-05-16)
Docosahexaenoic acid (DHA) is an omega-3 fatty acid that is essential for normal brain growth and cognitive function. Consistent with its importance in the brain, DHA is highly enriched in brain phospholipids. Despite being an abundant fatty acid in brain

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