PRS2325

Anti-CASPASE-12 (ab1) antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

• Sinónimos: Anti-Casp-12
• MDL number: MFCD03454856
• UNSPSC Code: 12352203
• NACRES: NA.41

Propiedades

• biological source: rabbit
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: predicted mol wt 46 kDa
• species reactivity: rat, mouse, human
• technique(s): immunohistochemistry: suitable; indirect ELISA: suitable; western blot: suitable
• UniProt accession no.: O08736
• shipped in: dry ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: mouse ... Casp12(12364)

Descripción

General description

Caspase 12 (CASP12), a member of the caspase family, is expressed in the Golgi complex.

Immunogen

a peptide corresponding to amino acids 2-17 of murine caspase-12.

Application

Anti-CASPASE-12 (ab1) antibody produced in rabbit has been used in western blotting.

Biochem/physiol Actions

Murine caspase 12 (CASP12) is activated during endoplasmic reticulum stress and activates other caspases which act on substrates, ultimately leading to apoptosis. The protein has been shown to be activated during progression of retinal degeneration in animal models. In mice models, CASP12 has been shown to cause neuronal death resulting from ischemia/reperfusion.

Linkage

The action of this antibody can be blocked using blocking peptide SBP2325.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable