PHG0005

BIS-TRIS propano

• Sinónimos: 1,3-bis[tris(hidroximetil)metilamino]propano
• Fórmula lineal: CH₂[CH₂NHC(CH₂OH)₃]₂
• Número de CAS: 64431-96-5
• Peso molecular: 282.33
• Beilstein: 1786109
• Número CE: 264-899-3
• Número MDL: MFCD00004689
• Código UNSPSC: 12161705
• NACRES: NA.21

Propiedades

• origen biológico: synthetic
• Nivel de calidad: 400
• Formulario: powder
• técnicas: cell culture | mammalian: suitable
• impurezas: Endotoxin, microbial, and trace metals; tested
• intervalo de pH útil: 6.3-9.5
• pKa (25 °C): (1) 6.8, (2) 9.0
• mp: 164-165 °C (lit.)
• idoneidad: suitable for manufacturing use
• actividad extraña: Cytotoxicity, DNase, NICKase, RNase, and Protease; tested
• cadena SMILES: OCC(CO)(CO)NCCCNC(CO)(CO)CO
• InChI: 1S/C11H26N2O6/c14-4-10(5-15,6-16)12-2-1-3-13-11(7-17,8-18)9-19/h12-19H,1-9H2
• Clave InChI: HHKZCCWKTZRCCL-UHFFFAOYSA-N

Descripción

Descripción general

Our SAFC^® portfolio of high-quality raw materials for use in biopharmaceutical processing withstands strict quality control procedures plus the documentation and expertise to help our customers meet requirements as defined by the M-Clarity Program.

M-Clarity Program

Buffer quality is vital for the success of biopharmaceutical processes, because buffers are indispensable in nearly every production step.

Our broad portfolio of buffer materials manufactured under appropriate controls is tailored to your needs. Ranging from non-GMP grades for low-risk application, to IPEC-PQG GMP for higher-risk applications, we have products covering all your manufacturing needs.

Aplicación

Bis Tris Propane is a unique biological buffer also referred to as a “Universal” buffer, which means the buffer capacity covers a wide range. Bis Tris Propane has two pKas of 6.3 and 9.5, which expands the buffering range from 5.0-10.5-making this a versatile buffer for biological systems. Bis Tris Propane is considered to be non-toxic to culture cell lines and provides high-solution clarity.

A review of DNA polymerase techniques lists bis tris propane as a suitable buffer for PCR methods as a universal buffer pH gradient is employed.

Información legal

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable