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N4505

Sigma-Aldrich

β-Nicotinamide adenine dinucleotide, reduced dipotassium salt

Sinónimos:

β-DPNH, β-NADH, DPNH, Diphosphopyridine nucleotide, reduced form, NADH

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About This Item

Fórmula lineal:
C21H27N7O14P2K2
Número de CAS:
104809-32-7
Peso molecular:
741.62
Número MDL:
MFCD00079494
Código UNSPSC:
41106305
ID de la sustancia en PubChem:
24897704
NACRES:
NA.51

origen biológico

synthetic

Nivel de calidad

200

Ensayo

≥95%

Formulario

powder

solubilidad

10 mM NaOH: soluble-100 mg/mL, clear to hazy, faintly yellow to yellow

temp. de almacenamiento

−20°C

cadena SMILES

[K].NC(=O)C1=CN(C=CC1)C2OC(COP(O)(=O)OP(O)(=O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O

InChI

1S/C21H29N7O14P2.K.H/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33;;/h1,3-4,7-8,10-11,13-16,20-21,29-32H,2,5-6H2,(H2,23,33)(H,34,35)(H,36,37)(H2,22,24,25);;

Clave InChI

KMRPNNQOKAHXEZ-UHFFFAOYSA-N

Información sobre el gen

human ... IMPDH2(3615)

Aplicación

β-Nicotinamide adenine dinucleotide (NAD+) and β-Nicotinamide adenine dinucleotide, reduced (NADH) comprise a coenzyme redox pair (NAD+:NADH) involved in a wide range of enzyme catalyzed oxidation reduction reactions. In addition to its redox function, NAD+/NADH is a donor of ADP-ribose units in ADP-ribosylaton (ADP-ribosyltransferases; poly(ADP-ribose) polymerases ) reactions and a precursor of cyclic ADP-ribose (ADP-ribosyl cyclases).

Acciones bioquímicas o fisiológicas

Electron donor

Otras notas

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number
0000399968
0000398289
0000263175
0000398290
0000364531

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Luisa Schwarzmann et al.
Bioscience reports, 41(1) (2021-01-05)
Nicotinamide adenine dinucleotide (NAD) is a coenzyme in metabolic reactions and cosubstrate in signaling pathways of cells. While the intracellular function of NAD is well described, much less is known about its importance as an extracellular molecule. Moreover, there is
Cornelia Wetzker et al.
Scientific reports, 9(1), 19534-19534 (2019-12-22)
Metabolic profiles vary across all levels of biological diversity, from cells to taxa. Two-photon fluorescence lifetime imaging microscopy (FLIM) facilitates metabolic characterisation of biological specimens by assaying the intrinsic autofluorescence of the ubiquitous coenzymes NAD(P)H and FAD. The potential of
Sritama De Sarkar et al.
Parasitology research, 118(1), 335-345 (2018-11-25)
Berberine chloride, a plant-derived isoquinoline alkaloid, has been demonstrated to have leishmanicidal activity, which is mediated by generation of a redox imbalance and depolarization of the mitochondrial membrane, resulting in a caspase-independent apoptotic-like cell death. However, its impact on mitochondrial
Erika Chacin et al.
Nature communications, 12(1), 5224-5224 (2021-09-03)
The replication of chromosomes during S phase is critical for cellular and organismal function. Replicative stress can result in genome instability, which is a major driver of cancer. Yet how chromatin is made accessible during eukaryotic DNA synthesis is poorly
Peter M Fernandes et al.
The FEBS journal, 287(13), 2847-2861 (2019-12-16)
Trypanosomatids possess glycosome organelles that contain much of the glycolytic machinery, including phosphofructokinase (PFK). We present kinetic and structural data for PFK from three human pathogenic trypanosomatids, illustrating intriguing differences that may reflect evolutionary adaptations to differing ecological niches. The
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