M9445
Matrix Metalloproteinase-2 from mouse
recombinant, expressed in NSO cells, >95% (SDS-PAGE), buffered aqueous glycerol solution
Sinónimos:
72 kD Gelatinase, 72 kD Type IV Collagenase, Gelatinase A, MMP-2
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About This Item
Productos recomendados
recombinante
expressed in NSO cells
Nivel de calidad
Ensayo
>95% (SDS-PAGE)
Formulario
buffered aqueous glycerol solution
mol peso
apparent mol wt ~72 kDa
Condiciones de envío
wet ice
temp. de almacenamiento
−20°C
Información sobre el gen
mouse ... Mmp2(17390)
rat ... Mmp2(81686)
Descripción general
Matrix Metalloproteinase-2 (MMP-2) also known as gelatinase or type IV collagenase is a 72kDa protein. MMP-2 is a member of matrix metalloproteinase (MMP) family of enzymes. Basic structure of MMP2 contains signal peptide domain that targets the enzyme for secretion, the pro-peptide domain, which is removed when the enzyme is activated and the catalytic site containing gelatin-binding domain.
Especificidad
The amino acid sequences 1-662 of the proenzymes of MMP-2 are identical between mouse and rat.
Aplicación
Matrix metalloproteinase-2 (MMP2) human has been used as a standard in zymography to measure proteolytic activity of MMP-2.
Acciones bioquímicas o fisiológicas
MMP-2 degrades general matrix components and may have a role in processes such as host defense, cell proliferation, and protein turnover as well as tissue remodeling.
Matrix Metalloproteinase-2 (MMP-2) cleaves gelatin, type IV, V, VII, X, and XI collagens, fibronectin, elastin, laminin, proteoglycans and a range of non extracellular matrix (ECM ) components. MMP-2 cleaves native type I collagen to N-terminal ¾ and C-terminal ¼ fragments identical to those generated by interstitial collagenases. MMP2 and MMP9 play an essential role in matrix degradation and they are implicated in the maintenance of neovascularization. In mice, deletion or inhibition of MMP2 protects against myocardial rupture.
Forma física
Supplied as a 0.2 μm filtered solution of 25 mM Tris, pH 7.5, 5 mM calcium chloride, 75 mM sodium chloride, 0.025% Brij® 35 and 50% glycerol.
Nota de análisis
The biological activity is measured by its ability to cleave a fluorogenic peptide sustrate.
Información legal
Brij is a registered trademark of Croda International PLC
Código de clase de almacenamiento
12 - Non Combustible Liquids
Clase de riesgo para el agua (WGK)
WGK 2
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Equipo de protección personal
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
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Los clientes también vieron
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(Stick Pigeon).
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Vos MC
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Thrombospondin-1 suppresses spontaneous tumor growth and inhibits activation of matrix metalloproteinase-9 and mobilization of vascular endothelial growth factor.
Rodriguez-Manzaneque JC
Proceedings of the National Academy of Sciences of the USA, 98(22), 12485-12490 (2001)
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