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M7316

Sigma-Aldrich

Monoamine Oxidase A human

recombinant, expressed in baculovirus infected BTI insect cells

Sinónimos:

MAO-A, MAOA

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About This Item

Comisión internacional de enzimas:
1.4.3.4 (BRENDA, IUBMB)
Número MDL:
MFCD04040932
Código UNSPSC:
12352204
NACRES:
NA.54

recombinante

expressed in baculovirus infected BTI insect cells

Nivel de calidad

100

Formulario

liquid

envase

vial of ~2.5 mg

Nº de acceso UniProt

P21397

Condiciones de envío

dry ice

temp. de almacenamiento

−70°C

Información sobre el gen

human ... MAOA(4128)

Descripción general

Monoamine Oxidase A contains binding sites for 8α-S-cysteinyl-FAD.
Monoamine oxidases metabolize biogenic amines in the central nervous system and the peripheral tissue.

Aplicación

Monoamine Oxidase A has been used in a study to assess abnormal behavior in a large kindred of males where a deficiency of enzymatic activity of monamine oxidase A was found. It has also been used in a study to investigate an association between smoking and the inhibition of MAOA.

Acciones bioquímicas o fisiológicas

MAO′s are proteins of the mitochondrial membrane. These enzymes are responsible for catalyzing oxidative deamination of endo- and xenobiotic amines. Substrate specificity differs for each isozyme.

Código de clase de almacenamiento

12 - Non Combustible Liquids

Clase de riesgo para el agua (WGK)

WGK 1

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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Certificados de análisis (COA)

Lot/Batch Number
SLCQ3663
0000280787
SLCQ1101
SLCN5941
SLCN5939

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J S Fowler et al.
Proceedings of the National Academy of Sciences of the United States of America, 93(24), 14065-14069 (1996-11-26)
Several studies have documented a strong association between smoking and depression. Because cigarette smoke has been reported to inhibit monoamine oxidase (MAO) A in vitro and in animals and because MAO A inhibitors are effective antidepressants, we tested the hypothesis
Ryuichi Harada et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 62(2), 253-258 (2020-07-11)
Reactive astrocytes play a key role in the pathogenesis of various neurodegenerative diseases. Monoamine oxidase-B (MAO-B) is one of the promising targets for the imaging of astrogliosis in the human brain. A novel selective and reversible MAO-B tracer, (S)-(2-methylpyrid-5-yl)-6-[(3-18F-fluoro-2-hydroxy)propoxy]quinoline (18F-SMBT-1)
Wenping Wang et al.
Antioxidants (Basel, Switzerland), 10(10) (2021-10-24)
Neurotransmitter catecholamines (dopamine, epinephrine, and norepinephrine) are liable to undergo oxidation, which copper is deeply involved in. Catecholamine oxidation-derived neurotoxicity is recognized as a pivotal pathological mechanism in neurodegenerative diseases. Glutamate, as an excitatory neurotransmitter, is enriched in the brain
Marcus A Maher et al.
Analytical and bioanalytical chemistry, 408(3), 695-703 (2015-11-18)
The need for rapid and cost-effective pre-screening protocols of the toxicological response of the vast array of emerging nanoparticle types is apparent and the emerging consensus on the paradigm of oxidative stress by generation of intracellular reactive oxygen species as
Moussa B H Youdim et al.
Nature reviews. Neuroscience, 7(4), 295-309 (2006-03-23)
Monoamine oxidase inhibitors were among the first antidepressants to be discovered and have long been used as such. It now seems that many of these agents might have therapeutic value in several common neurodegenerative conditions, independently of their inhibition of
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Serotonin Synthesis & Metabolism

Serotonin is stored in cells and metabolized by MAO, influencing CNS, GI, and platelet functions.

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Serotonin is stored in cells and metabolized by MAO, influencing CNS, GI, and platelet functions.

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