M4074

Mometasone furoate

≥98% (HPLC)

• Sinónimos: (11β,16α)-9,21-Dichloro-17-[(2-furanylcarbonyl)oxy]-11-hydroxy-16-methylpregna-1,4-diene-3,20-dione
• Fórmula empírica (notación de Hill): C₂₇H₃₀Cl₂O₆
• Número de CAS: 83919-23-7
• Peso molecular: 521.43
• Número MDL: MFCD00866003
• Código UNSPSC: 51111800
• ID de la sustancia en PubChem: 329817988
• NACRES: NA.77

Propiedades

• Nivel de calidad: 100
• Ensayo: ≥98% (HPLC)
• Formulario: powder
• actividad óptica: [α]/D +50 to +60°, c = 0.5 in methanol
• color: white to off-white
• solubilidad: DMSO: ≥20 mg/mL
• emisor: Schering Plough
• temp. de almacenamiento: 2-8°C
• cadena SMILES: C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(Cl)[C@@H](O)C[C@]2(C)[C@@]1(OC(=O)c5ccco5)C(=O)CCl
• InChI: 1S/C27H30Cl2O6/c1-15-11-19-18-7-6-16-12-17(30)8-9-24(16,2)26(18,29)21(31)13-25(19,3)27(15,22(32)14-28)35-23(33)20-5-4-10-34-20/h4-5,8-10,12,15,18-19,21,31H,6-7,11,13-14H2,1-3H3/t15-,18+,19+,21+,24+,25+,26+,27+/m1/s1
• Clave InChI: WOFMFGQZHJDGCX-ZULDAHANSA-N
• Información sobre el gen: human ... NR3C1(2908)

Descripción

Aplicación

Mometasone furoate has been used to study its effect on Leishmania major amastigotes.

Acciones bioquímicas o fisiológicas

Mometasone furoate is a 17-heterocyclic intranasal corticosteroid. It is effectively used as a first-line daily intranasal therapeutic for allergic rhinitis and nasal polyposis. Mometasone furoate is also used as an adjunct to anti-bacterials for treating acute rhinosinusitis. In addition, it relieves the symptoms of asthma in both adults and adolescents by exhibiting a broad spectrum of anti-inflammatory properties.

Mometasone furoate is an anti-inflammatory glucocorticoid.

Características y beneficios

This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Schering Plough. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Información de seguridad

• Pictogramas: GHS08
• Palabra de señalización: Danger
• Frases de peligro: H360D
• Consejos de prudencia: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Clasificaciones de peligro: Repr. 1B
• Código de clase de almacenamiento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable