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L2387

Sigma-Aldrich

Lipopolysaccharides from Salmonella typhosa

purified by gel-filtration chromatography

Sinónimos:

LPS

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About This Item

Número MDL:
MFCD00131520
Código UNSPSC:
12352201
NACRES:
NA.25

origen biológico

bacterial (Salmonella typhosa)

Nivel de calidad

200

Formulario

lyophilized powder

purificado por

gel-filtration chromatography

impurezas

<1% Protein

color

white to faint yellow

solubilidad

water: soluble

temp. de almacenamiento

2-8°C

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Categorías relacionadas

Descripción general

This product is extracted from Salmonella typhosa and purified by gel filtration. The source strain is ATCC 10749.

Aplicación

Lipopolysaccharides (LPSs) are characteristic components of the cell wall of Gram-negative bacteria. LPS and its lipid A moiety stimulate cells of the innate immune system by the Toll-like receptor 4 (TLR4), a member of the Toll-like receptor protein family, which recognizes common pathogen-associated molecular-patterns (PAMPs).

Acciones bioquímicas o fisiológicas

Lipopolysaccharides (LPS) are localized in the outer layer of the membrane and are, in noncapsulated strains, exposed on the cell surface. They contribute to the integrity of the outer membrane, and protect the cell against the action of bile salts and lipophilic antibiotics.

Nota de preparación

The product is soluble in water (5 mg/ml) or cell culture medium (1 mg/ml) yielding a hazy, faint yellow solution. A more concentrated, though still hazy, solution (20 mg/ml) has been achieved in aqueous saline after vortexing and warming to 70-80 oC. Lipopolysaccharides are molecules that form micelles in every solvent. Hazy solutions are observed in water and phosphate buffered saline. Organic solvents do not give clearer solutions. Methanol yields a turbid suspension with floaters, while water yields a homogeneously hazy solution.

Otras notas

To gain a comprehensive understanding of our extensive range of Lipopolysaccharides for your research, we encourage you to visit our Carbohydrates Category page.

Producto relacionado

Referencia del producto
Descripción
Precios

Pictogramas

Skull and crossbones
GHS06

Palabra de señalización

Danger

Frases de peligro

H300

Clasificaciones de peligro

Acute Tox. 2 Oral

Código de clase de almacenamiento

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number
0000369116
0000369116
0000348128
0000274788
0000242472

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Visite la Librería de documentos

Malick M Gibani et al.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 68(8), 1265-1273 (2018-09-27)
Shedding of Salmonella Typhi or Paratyphi in the stool or urine leads to contamination of food or water, which is a prerequisite for transmission of enteric fever. Currently, there are limited data on the effect of vaccination or prior exposure
Thomas C Darton et al.
Frontiers in microbiology, 8, 1794-1794 (2017-10-04)
Current diagnostic tests for typhoid fever, the disease caused by
Claire S Waddington et al.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 58(9), 1230-1240 (2014-02-13)
Typhoid fever is a major global health problem, the control of which is hindered by lack of a suitable animal model in which to study Salmonella Typhi infection. Until 1974, a human challenge model advanced understanding of typhoid and was
Thomas C Darton et al.
PLoS neglected tropical diseases, 10(8), e0004926-e0004926 (2016-08-18)
Typhoid persists as a major cause of global morbidity. While several licensed vaccines to prevent typhoid are available, they are of only moderate efficacy and unsuitable for use in children less than two years of age. Development of new efficacious
Malick M Gibani et al.
PLoS neglected tropical diseases, 14(10), e0008783-e0008783 (2020-10-21)
Enteric fever is a systemic infection caused by Salmonella Typhi or Paratyphi A. In many endemic areas, these serovars co-circulate and can cause multiple infection-episodes in childhood. Prior exposure is thought to confer partial, but incomplete, protection against subsequent attacks
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Explore the structure, function, and diverse applications of Lipopolysaccharides. Discover their role in bacteria, serological specificity, and research potential.

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Contenido relacionado

Lipopolysaccharides

Lipopolysaccharide (LPS) is a major component of Gram-negative bacteria, important for microbiological research.

Lipopolysaccharides

Lipopolysaccharide (LPS) is a major component of Gram-negative bacteria, important for microbiological research.

Lipopolysaccharides

Lipopolysaccharide (LPS) is a major component of Gram-negative bacteria, important for microbiological research.

Lipopolysaccharides

Lipopolysaccharide (LPS) is a major component of Gram-negative bacteria, important for microbiological research.

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