I8898

Ivermectin

• Sinónimos: 22,23-Dihydroavermectin B1, MK-933
• Número de CAS: 70288-86-7
• Número MDL: MFCD00869511
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 24278497
• NACRES: NA.77

Propiedades

• Formulario: powder
• solubilidad: MEK: 50 mg/mL
• espectro de actividad antibiótica: parasites
• aplicaciones: agriculture; environmental
• Modo de acción: cell membrane | interferes
• emisor: Merck & Co., Inc., Kenilworth, NJ, U.S.
• temp. de almacenamiento: 2-8°C
• cadena SMILES: [H][C@@]1(O[C@]2(CC[C@@H]1C)C[C@@H]3C[C@@H](C\C=C(C)\[C@@H](O[C@H]4C[C@H](OC)[C@@H](O[C@H]5C[C@H](OC)[C@@H](O)[C@H](C)O5)[C@H](C)O4)[C@@H](C)\C=C\C=C6/CO[C@]7([H])[C@H](O)C(C)=C[C@@H](C(=O)O3)[C@]67O)O2)[C@@H](C)CC
• InChI: 1S/C48H74O14/c1-11-25(2)43-28(5)17-18-47(62-43)23-34-20-33(61-47)16-15-27(4)42(26(3)13-12-14-32-24-55-45-40(49)29(6)19-35(46(51)58-34)48(32,45)52)59-39-22-37(54-10)44(31(8)57-39)60-38-21-36(53-9)41(50)30(7)56-38/h12-15,19,25-26,28,30-31,33-45,49-50,52H,11,16-18,20-24H2,1-10H3/b13-12+,27-15+,32-14+/t25-,26-,28-,30-,31-,33+,34-,35-,36-,37-,38-,39-,40+,41-,42-,43+,44-,45+,47+,48+/m0/s1
• Clave InChI: AZSNMRSAGSSBNP-XPNPUAGNSA-N
• Información sobre el gen: human ... ABCB1(5243) , CYP3A4(1576) ; mouse ... Abcb1a(18671) , Abcb1b(18669)

Descripción

Descripción general

Ivermectin is a macro-cyclic lactone, derived from avermectin. It functions as an antiparasitic agent. Ivermectin is used against gastrointestinal roundworms, lungworms, mites and lice. It is used to treat onchocerciasis, strongyloidiasis, ascariasis and filariases.

Aplicación

Ivermectin has been used:

• in Caenorhabditis elegans fecundity assay
• in larval development test
• to measure in vivo topical acaricide activity of compounds in rats
• to assess its acute and chronic effects to zebrafish
• in percutaneous drug injection method to treat cystic echinococcosis
• in liquid chromatography with fluorescence detection method

Acciones bioquímicas o fisiológicas

Positive allosteric modulator of α7 neuronal nicotinic acetylcholine receptor; also modulates glutamate-GABA-activated chloride channels.

Características y beneficios

This compound is featured on the Acetylcholine Receptors (Nicotinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S.. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Otras notas

Primarily ivermectin B_1a.

Información de seguridad

• Pictogramas: GHS06,GHS08,GHS09
• Palabra de señalización: Danger
• Frases de peligro: H300,H311,H351,H360D,H410
• Consejos de prudencia: P202 - P264 - P273 - P280 - P301 + P310 - P302 + P352 + P312
• Clasificaciones de peligro: Acute Tox. 1 Oral - Acute Tox. 3 Dermal - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 2 - Repr. 1B
• Código de clase de almacenamiento: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges