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I4144

Sigma-Aldrich

IL-3 mouse

≥98% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

Sinónimos:

IL-3, mIL-3, Interleukin-3 from mouse

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About This Item

Número MDL:
MFCD00164817
Código UNSPSC:
12352202
NACRES:
NA.77

Nombre del producto

Interleukin-3 from mouse, IL-3, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

origen biológico

mouse

Nivel de calidad

200

recombinante

expressed in E. coli

Ensayo

≥98% (SDS-PAGE)

Formulario

lyophilized powder

potencia

0.01-0.1 ng/mL ED50/EC50

calidad

endotoxin tested

mol peso

15.1 kDa

envase

pkg of 10 and 50 μg

técnicas

cell culture | mammalian: suitable

impurezas

≤1.000 EU/μg

color

white to yellow

Nº de acceso UniProt

P01586

temp. de almacenamiento

−20°C

Información sobre el gen

mouse ... Il3(16187)

Descripción general

Interleukin-3 is a hematopoietic growth factor, which stimulates basophil development and triggers histamine, IL-4 and IL-6 release. It improves monocyte and macrophage activation and phagocytosis, enhances the secretory function of eosinophils. Interleukin-3 promotes endothelial cell proliferation and migration.

Aplicación

Interleukin-3 from mouse has been used for the determination of 5-lipoxygenase product leukotriene C4 (LTC4) formation. It has also been used as a component of RPMI 1640 medium for cell transfection.

Acciones bioquímicas o fisiológicas

Interleukin-3 (IL-3) is a multifunctional protein, originally called colony forming unit-stimulating activity (CFU-SA), and is produced by activated T lymphocytes. IL-3 supports the formation of multilineage colonies in the early development of multipotent hematopoietic progenitor cells. IL-3 has been shown to induce colony formation of macrophages, neutrophils, mast cells, and megakaryocytes from agar-suspended bone marrow cells. IL-3 also interacts with IL-2 to stimulate growth of T lymphocytes and to induce IgG secretion from activated B cells. Other synonyms for IL-3 include pan-specific hemopoietin, multicolony stimulating factor, mast cell growth factor, burst promoting activity, histamine-producing cell stimulating factor, P cell stimulating factor, and WEHI-3 factor.

Forma física

Lyophilized with 0.5 mg of bovine serum albumin. Sterile filtered through a 0.2 μm filter.

Nota de análisis

The biological activity is measured by the dose-dependent stimulation of the proliferation of mouse M-NFS-60 cells.

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

Eyeshields, Gloves, type N95 (US)

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Certificados de análisis (COA)

Lot/Batch Number
0000198106
0000198106
0000091275
0000299608

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Michèle Wiederkehr-Adam et al.
The Journal of biological chemistry, 278(18), 16117-16128 (2003-02-20)
Signal transducers and activators of transcription (STAT) 1 and STAT3 are activated by overlapping but distinct sets of cytokines. STATs are recruited to the different cytokine receptors through their Src homology (SH) 2 domains that make highly specific interactions with
Synthesis and evaluation of benzoxazole derivatives as 5-lipoxygenase inhibitors
Song H, et al.
Bioorganic & Medicinal Chemistry, 18(21), 7580-7585 (2010)
Characterization of phosphopeptide motifs specific for the Src homology 2 domains of signal transducer and activator of transcription 1 (STAT1) and STAT3
Wiederkehr-Adam M, et al.
Test, 278(18), 16117-16128 (2003)
Interleukin-3-deficient mice have increased resistance to blood-stage malaria.
Auclair SR et al
Infection and Immunity, 82(3), 1308-1314 (2014)
Serena De Vita et al.
PloS one, 9(5), e96209-e96209 (2014-05-03)
Systemic Mastocytosis (SM) is a clonal disease characterized by abnormal accumulation of mast cells in multiple organs. Clinical presentations of the disease vary widely from indolent to aggressive forms, and to the exceedingly rare mast cell leukemia. Current treatment of
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