H9636

Hypoxanthine

powder, suitable for cell culture, BioReagent

• Sinónimos: 6-Hydroxypurine
• Fórmula empírica (notación de Hill): C₅H₄N₄O
• Número de CAS: 68-94-0
• Peso molecular: 136.11
• Beilstein/REAXYS Number: 5811
• EC Number: 200-697-3
• MDL number: MFCD00005725
• UNSPSC Code: 12352207
• PubChem Substance ID: 24895864
• NACRES: NA.75

Propiedades

• product name: Hypoxanthine, powder, BioReagent, suitable for cell culture
• product line: BioReagent
• assay: ≥99%
• form: powder
• technique(s): cell culture | mammalian: suitable
• mp: >300 °C (lit.)
• solubility: formic acid: water (2:1): 50 mg/mL
• SMILES string: O=C1NC=Nc2nc[nH]c12
• InChI: 1S/C5H4N4O/c10-5-3-4(7-1-6-3)8-2-9-5/h1-2H,(H2,6,7,8,9,10)
• InChI key: FDGQSTZJBFJUBT-UHFFFAOYSA-N

Descripción

General description

Hypoxanthine (6-hydroxypurine), a purine derivative is a naturally occurring compound. It is the deaminated form of adenine and a breakdown product of adenosine monophosphate (AMP).

Application

Hypoxanthine is a nutrient additive for a variety of cell culture applications involving bacterial, parasite (Plasmodium falciparum) and animal cells. Hypoxanthine is a component of selection media used in hybridoma technologies.

Hypoxanthine has been used:

• as a supplement in HEPES (4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid) -buffered Roswell park memorial institute (RPMI) to culture Plasmodium falciparum strain IT/FCR3
• in the preparation of Dulbecco′s modified eagle′s medium (DMEM) + MXH for the selection of chimeric modified vaccinia virus ankara (MVA)
• to generate superoxide anions
• to prepare hybridoma selection and maintenance media.

Biochem/physiol Actions

Hypoxanthine is capable of stimulating cell death. It can also induce reactive oxygen species (ROS). It results in endothelial dysfunction via apoptosis, stimulated by oxidative stress.

Información de seguridad

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)