GW21317
Anti-RGS12 (ab1) antibody produced in chicken
affinity isolated antibody, buffered aqueous solution
Sinónimos:
Anti-Regulator of G-protein signaling 12
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About This Item
Código UNSPSC:
12352203
NACRES:
NA.41
Productos recomendados
origen biológico
chicken
conjugado
unconjugated
forma del anticuerpo
affinity isolated antibody
tipo de anticuerpo
primary antibodies
clon
polyclonal
Formulario
buffered aqueous solution
reactividad de especies
rat, mouse, human
fabricante / nombre comercial
Genway 15-288-21317
técnicas
western blot: suitable
Nº de acceso NCBI
Nº de acceso UniProt
Condiciones de envío
wet ice
temp. de almacenamiento
−20°C
modificación del objetivo postraduccional
unmodified
Información sobre el gen
human ... RGS12(6002)
Categorías relacionadas
Descripción general
Regulator of G-protein signaling 12 is a protein encoded by the RGS12 gene in humans belonging to the RGS protein family. It is a nuclear protein that exhibits a unique pattern of subnuclear organization into nuclear foci or dots when expressed endogenously or ectopically. RGS12 consists of alternatively spliced PDZ domain by which RGS proteins may target specific G-protein-coupled receptor systems for desensitization.
Inmunógeno
Immunogen Sequence: GI # 38327601, sequence 1372-1447
Recombinant regulator of G-protein signalling 12 isoform 1
Aplicación
Anti-RGS12 (ab1) antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
Acciones bioquímicas o fisiológicas
Regulator of G-protein signaling 12 plays a role during alternative splicing and cell cycle-dependent mechanisms in expression and subnuclear targeting of RGS12 proteins. RGS12 possesses a novel structure and function in the nucleus and the biological activities are distinct from those of other members of the RGS protein family.
Forma física
Solution in phosphate buffered saline containing 0.02% sodium azide.
Cláusula de descargo de responsabilidad
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Código de clase de almacenamiento
10 - Combustible liquids
Clase de riesgo para el agua (WGK)
WGK 1
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Equipo de protección personal
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
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Gongsheng Yuan et al.
Cell insight, 1(5), 100055-100055 (2023-05-17)
Angiogenesis is the formation of new capillaries that plays an essential role in the pathogenesis of inflammatory arthritis. However, the cellular and molecular mechanisms remain unclear. Here, we provide the first evidence that regulator of G-protein signaling 12 (RGS12) promotes
Anil Akturk et al.
Science advances, 8(42), eabq2826-eabq2826 (2022-10-20)
Inhibitory G proteins (GNAI/Gαi) bind to the scaffold G protein signaling modulator 2 (GPSM2) to form a conserved polarity complex that regulates cytoskeleton organization. GPSM2 keeps GNAI in a guanosine diphosphate (GDP)-bound state, but how GPSM2-GNAI is generated or relates
B E Snow et al.
The Journal of biological chemistry, 273(28), 17749-17755 (1998-07-04)
Regulator of G-protein signaling (RGS) proteins increase the intrinsic guanosine triphosphatase (GTPase) activity of G-protein alpha subunits in vitro, but how specific G-protein-coupled receptor systems are targeted for down-regulation by RGS proteins remains uncharacterized. Here, we describe the GTPase specificity
Tapan K Chatterjee et al.
Molecular and cellular biology, 22(12), 4334-4345 (2002-05-25)
RGS12TS-S, an 1,157-amino-acid RGS protein (regulator of G protein signaling), is a nuclear protein that exhibits a unique pattern of subnuclear organization into nuclear foci or dots when expressed endogenously or ectopically. We now report that RGS12TS-S is a nuclear
Gongsheng Yuan et al.
Annals of translational medicine, 9(6), 448-448 (2021-04-15)
Pain is a predominant symptom in rheumatoid arthritis (RA) patients that results from joint inflammation and is augmented by central sensitization. Regulator of G-protein signaling 12 (RGS12) is the largest protein in the RGS protein family and plays a key
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