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D9035

Sigma-Aldrich

Diazoxide

≥98% (TLC), powder, ATP-sensitive K⁺ channel activator

Sinónimos:

7-Chloro-3-methyl-2H-1,2,4-benzothiadiazine 1,1-dioxide

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About This Item

Fórmula empírica (notación de Hill):
C8H7ClN2O2S
Número de CAS:
364-98-7
Peso molecular:
230.67
EC Number:
206-668-1
MDL number:
MFCD00078578
UNSPSC Code:
12352119
PubChem Substance ID:
24277831
NACRES:
NA.77

product name

Diazoxide,

form

powder

solubility

0.1 M NaOH: soluble
H2O: insoluble
methanol: soluble

originator

Schering Plough

SMILES string

CC1=Nc2ccc(Cl)cc2S(=O)(=O)N1

InChI

1S/C8H7ClN2O2S/c1-5-10-7-3-2-6(9)4-8(7)14(12,13)11-5/h2-4H,1H3,(H,10,11)

InChI key

GDLBFKVLRPITMI-UHFFFAOYSA-N

Gene Information

human ... KCNA1(3736) , KCNJ11(3767) , KCNJ8(3764) , KCNMA1(3778)
mouse ... Kcnj1(56379) , Kcnj11(16514)
rat ... Gria1(50592) , Kcna1(24520) , Kcnj1(24521) , Kcnj11(83535) , Kcnj8(25472)

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General description

Diazoxide is a nondiuretic benzothiadiazine, which is used for the treatment of hypoglycemia, von Gierke′s disease, acute and malignant hypertension. It acts as a beta cell KATP channel opener. Diazoxide prevents the secretion of insulin.

Application

Diazoxide has been used for diazoxide infusion. It has also been used to prevent depolarization for K+-induced exocytosis.

Biochem/physiol Actions

Selective ATP-sensitive K+ channel activator in both vascular smooth muscle and pancreatic β-cells; antihypertensive.

Features and Benefits

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Schering Plough. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Visite la Librería de documentos

T Grimmsmann et al.
British journal of pharmacology, 123(5), 781-788 (1998-04-16)
1. The direct effects of diazoxide on mitochondrial membrane potential, Ca2+ transport, oxygen consumption and ATP generation were investigated in mouse pancreatic B-cells and rat liver mitochondria. 2. Diazoxide, at concentrations commonly used to open adenosine 5'-triphosphate (ATP)-dependent K+-channels (K(ATP)
Glucose-dependent granule docking limits insulin secretion and Is decreased in human type 2 diabetes
Gandasi NR, et al.
Cell Metabolism, 27(2), 470-478 (2018)
Pharmacological Preconditioning with Diazoxide in the Experimental Hypothermic Circulatory Arrest Model
Haapanen H, et al.
The Heart Surgery Forum (2017)
Diazoxide for Lowering Insulin Levels in Breast Cancer Patients.
Fink MK and Klement RJ
Oncologist, 22(4), 491-491 (2017)
N D'hahan et al.
Proceedings of the National Academy of Sciences of the United States of America, 96(21), 12162-12167 (1999-10-16)
The pharmacological phenotype of ATP-sensitive potassium (K(ATP)) channels is defined by their tissue-specific regulatory subunit, the sulfonylurea receptor (SUR), which associates with the pore-forming channel core, Kir6.2. The potassium channel opener diazoxide has hyperglycemic and hypotensive properties that stem from
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