C4397

Chlorzoxazone

• Sinónimos: 5-Chloro-2(3H)-benzoxazolone, 5-Chloro-2-hydroxybenzoxazole
• Fórmula empírica (notación de Hill): C₇H₄ClNO₂
• Número de CAS: 95-25-0
• Peso molecular: 169.57
• Número CE: 202-403-9
• Número MDL: MFCD00005717
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 24277702
• NACRES: NA.77

Propiedades

• Ensayo: ≥98% (TLC)
• Nivel de calidad: 100
• Formulario: powder
• color: white to off-white
• mp: 191-192 °C (lit.)
• solubilidad: DMSO: 50 mg/mL, clear
• emisor: Johnson & Johnson
• temp. de almacenamiento: room temp
• cadena SMILES: Clc1ccc2OC(=O)Nc2c1
• InChI: 1S/C7H4ClNO2/c8-4-1-2-6-5(3-4)9-7(10)11-6/h1-3H,(H,9,10)
• Clave InChI: TZFWDZFKRBELIQ-UHFFFAOYSA-N
• Información sobre el gen: human ... KCNN4(3783)

Descripción

Aplicación

Chlorzoxazone may be used:

• as a calcium-activated potassium (K_Ca) channel activator in patch-clamp electrophysiology to test its effect on dendritic hyperexcitability
• as a substrate for cytochrome P450 2E1 (CYP2E1) enzyme in cultured human hepatocytes
• as a benzimidazolone compound to test its effect on epithelial sodium (Na⁺) transport

Acciones bioquímicas o fisiológicas

Chlorzoxazone inhibits the multisynaptic reflex arcs primarily in the spinal cord and brain subcortical areas. It is an activator of calcium activated potassium channels and may contribute to the aortic artery relaxation in mice. Chlorzoxazone also activates the calcium-activated potassium (K_Ca) channel and small conductance calcium-activated potassium channels (SK). It is metabolized by cytochrome P450 2E1 (CYP2E1) and serves as a probe for monitoring this enzyme function.

Chlorzoxazone is a skeletal muscle relaxant.

Características y beneficios

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Información de seguridad

• Pictogramas: GHS07
• Palabra de señalización: Warning
• Frases de peligro: H302,H315,H319,H335
• Consejos de prudencia: P261 - P264 - P270 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• Clasificaciones de peligro: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Órganos de actuación: Respiratory system
• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: dust mask type N95 (US), Eyeshields, Gloves