C3021

Dicyanocobinamide

≥93%

• Sinónimos: Cobinamide dicyanide, Etiocobalamin, Factor B
• Fórmula empírica (notación de Hill): C₅₀H₇₂CoN₁₃O₈
• Número de CAS: 27792-36-5
• Peso molecular: 1042.12
• Número MDL: MFCD00056330
• Código UNSPSC: 12352205
• ID de la sustancia en PubChem: 24892558
• NACRES: NA.79

Propiedades

• origen biológico: synthetic (organic)
• Nivel de calidad: 200
• Ensayo: ≥93%
• Formulario: powder
• impurezas: ≤0.1% vitamin B₁₂
• color: purple to very dark purple
• temp. de almacenamiento: −20°C
• cadena SMILES: N#C[Co]C#N.C[C@H](O)CNC(=O)CC[C@]1(C)[C@@H](CC(N)=O)C2N=C1C(C)=C3N=C(C=C4N=C(C(C)=C5N[C@]2(C)[C@@](C)(CC(N)=O)[C@@H]5CCC(N)=O)[C@@](C)(CC(N)=O)[C@@H]4CCC(N)=O)C(C)(C)[C@@H]3CCC(N)=O
• InChI: 1S/C48H73N11O8.2CN.Co/c1-23(60)22-55-38(67)16-17-45(6)29(18-35(52)64)43-48(9)47(8,21-37(54)66)28(12-15-34(51)63)40(59-48)25(3)42-46(7,20-36(53)65)26(10-13-32(49)61)30(56-42)19-31-44(4,5)27(11-14-33(50)62)39(57-31)24(2)41(45)58-43;2*1-2;/h19,23,26-29,43,59-60H,10-18,20-22H2,1-9H3,(H2,49,61)(H2,50,62)(H2,51,63)(H2,52,64)(H2,53,65)(H2,54,66)(H,55,67);;;/b30-19-,39-24-,40-25-;;;/t23-,26+,27+,28+,29-,43?,45+,46-,47-,48-;;;/m0.../s1
• Clave InChI: NJATWHPHZUGTHR-GXEWULDJSA-N

Descripción

Descripción general

Dicyanocobinamide, also known as factor b is a coenzyme B12 precursor. It has a corrin ring structure with four of the six coordination sites of the cobalt (Co) atom being the pyrrole nitrogen atoms.

Aplicación

Dicyanocobinamide has been used for the crystallization of vitamin B₁₂-binding protein (BtuF). It has also been used for the destabilization of BtuCD-BtuF Interaction.

For use in determining non-intrinsic factor (R protein) in intrinsic factor preparations.

Acciones bioquímicas o fisiológicas

Dicyanocobinamide (Cbi) functions as a soluble guanylate cyclase (sGC) co-activator and targets the N-terminal regulatory regions. This action is similar to the effect of forskolin on adenylyl cyclases. Dicyanocobinamide elevates the intracellular cyclic guanosine monophosphate (cGMP) levels and exhibits vasorelaxant activity in rats. It is used along with various cobalamins in studies of the inhibition of HIV-1 integrase and nitric oxide synthase.

Información de seguridad

• Pictogramas: GHS07
• Palabra de señalización: Warning
• Frases de peligro: H302
• Clasificaciones de peligro: Acute Tox. 4 Oral
• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable