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Merck
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B016

Sigma-Aldrich

Benoxathian hydrochloride

solid

Sinónimos:

2-[[[2-(2,6-Dimethoxyphenoxy)ethyl]-amino]-methyl]-1,4-benzoxathian hydrochloride

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About This Item

Fórmula empírica (notación de Hill):
C19H23NO4S · HCl
Número de CAS:
92642-97-2
Peso molecular:
397.92
MDL number:
MFCD00055188
UNSPSC Code:
12352202
PubChem Substance ID:
24277758
NACRES:
NA.77

form

solid

Quality Level

100

color

white

solubility

H2O: soluble (Aqueous solutions may be stored for several weeks at -20 °C.)
ethanol: soluble
isopropanol: soluble

SMILES string

Cl.COc1cccc(OC)c1OCCNCC2CSc3ccccc3O2

InChI

1S/C19H23NO4S.ClH/c1-21-16-7-5-8-17(22-2)19(16)23-11-10-20-12-14-13-25-18-9-4-3-6-15(18)24-14;/h3-9,14,20H,10-13H2,1-2H3;1H

InChI key

OWRADFDDJVNMGL-UHFFFAOYSA-N

Gene Information

human ... ADRA1A(148) , ADRA1B(147) , ADRA1D(146)

Biochem/physiol Actions

Selective α1-adrenoceptor antagonist.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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A J Douglas et al.
Journal of neuroendocrinology, 17(1), 40-48 (2005-02-22)
We investigated whether changes in noradrenaline neurotransmission in the hypothalamus could explain the hyporesponsiveness of the hypothalamic-pituitary-adrenal (HPA) axis in late pregnancy. Noradrenaline release within the hypothalamic paraventricular nucleus in response to swim stress, as estimated by microdialysis and high-performance
Y Madrero et al.
British journal of pharmacology, 119(8), 1563-1568 (1996-12-01)
1. The selectivity of action of boldine and the related aporphine alkaloids, predicentrine (9-O-methylboldine) and glaucine (2,9-O-dimethylboldine) and alpha 1-adrenoceptor subtypes was studied by examining [3H]-prazosin competition binding in rat cerebral cortex. WB 4101 and benoxathian were used as selective
G J Marek et al.
European journal of pharmacology, 305(1-3), 95-100 (1996-06-03)
Pharmacological techniques have defined the existence of two different alpha 1-adrenoceptors, the alpha 1A- and alpha 1B-adrenoceptor subtypes and both of these receptors have been cloned in addition to a cloned alpha 1d-adrenoceptor. A subpopulation of interneurons in layer III
Cauveh Erami et al.
American journal of physiology. Heart and circulatory physiology, 283(4), H1577-H1587 (2002-09-18)
Previous studies suggesting that norepinephrine is directly trophic for the vascular wall have been confounded by concomitant hemodynamic disturbances. Herein, a microcatheter connected to an osmotic minipump was implanted adjacent to the rat carotid for 2-wk perivascular suffusion of agents
Adrenoceptors in normal and malignant human melanocytes.
A C Scarparo et al.
Archives of dermatological research, 292(5), 265-267 (2000-06-27)
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