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A6412

Sigma-Aldrich

Aflatoxin M1–BSA Conjugate

Sinónimos:

AFM1-BSA conjugate

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About This Item

Número MDL:
MFCD00130364
Código UNSPSC:
12352200
NACRES:
NA.77

Formulario

powder

Nivel de calidad

200

Extensión del etiquetado

4-8 mol aflatoxin M1 per mol BSA (Lowry)

temp. de almacenamiento

2-8°C

Descripción general

Aflatoxin M1 is a hydroxylated metabolite ofaflatoxin B1. It is found in milk secreted by mammary glands of lactatinganimals, humans, and milk products.

Aplicación

Aflatoxin M1–BSA Conjugate has been used in the indirect competitive enzyme-linked immunosorbent assay (ic-ELISA) with non-labeled aflatoxin M1 and anti-AFM1 antibody.

Acciones bioquímicas o fisiológicas

Aflatoxin M1 is a mycotoxin that elicits both hepatotoxic and hepatocarcinogenic effects leading to immunosuppression in animals. The bioconjugate of aflatoxin M1 (AFM1) with bovine serum albumin (BSA) is useful in the generation of AFM1 specific antibodies which may have immunoassay applications.

Advertencia

Possibly carcinogenic.

Pictogramas

Skull and crossbonesHealth hazard
GHS06,GHS08

Palabra de señalización

Danger

Frases de peligro

H300 + H310 + H330,H350

Clasificaciones de peligro

Acute Tox. 1 Inhalation - Acute Tox. 2 Dermal - Acute Tox. 2 Oral - Carc. 1B

Código de clase de almacenamiento

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Clase de riesgo para el agua (WGK)

WGK 3

Equipo de protección personal

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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Certificados de análisis (COA)

Lot/Batch Number
0000373968
0000354270
0000373968
0000354270
0000185045

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A Radoi et al.
Talanta, 77(1), 138-143 (2008-09-23)
Five different clones of antibodies developed against the aflatoxin M(1) were investigated by using the classical indirect and direct competitive Enzyme-Linked Immunosorbent Assay (ELISA) formats, and also the direct competitive ELISA based on the use of the superparamagnetic nanoparticles. The
Aflatoxin M1 in milk and dairy products, occurrence and recent challenges: A review
Iqbal S Z, et al.
Trends in Food Science & Technology, 46 (1) (2015)
Fatemeh Khademi et al.
Jundishapur journal of microbiology, 8(4), e16850-e16850 (2015-06-03)
Aflatoxins are the most extensively studied group of mycotoxins produced by molds, especially the Aspergillus group, which are highly toxic to animals and humans. Since immunoassay is a simple and rapid method for the analysis of many toxic substances in
K Thirumala-Devi et al.
Journal of agricultural and food chemistry, 50(4), 933-937 (2002-02-07)
High-titer rabbit polyclonal antibodies to aflatoxin M(1) (AFM1) were produced by utilizing AFM1-bovine serum albumin (BSA) conjugate as an immunogen. An indirect competitive enzyme-linked immunosorbent assay was standardized for estimating AFM1 in milk and milk products. To avoid the influence
Pradeep Kumar et al.
Frontiers in microbiology, 7, 2170-2170 (2017-02-02)
The aflatoxin producing fungi, Aspergillus spp., are widely spread in nature and have severely contaminated food supplies of humans and animals, resulting in health hazards and even death. Therefore, there is great demand for aflatoxins research to develop suitable methods

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