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A5971

Sigma-Aldrich

Anti-Water Channel Aquaporin 4 antibody produced in rabbit

lyophilized powder, affinity isolated antibody

Sinónimos:

Anti-AQP4, Anti-Mercurial-Insensitive Water Channel, Anti-WCH4

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About This Item

Número MDL:
Código UNSPSC:
12352203
NACRES:
NA.41

origen biológico

rabbit

Nivel de calidad

conjugado

unconjugated

forma del anticuerpo

affinity isolated antibody

tipo de anticuerpo

primary antibodies

clon

polyclonal

Formulario

lyophilized powder

reactividad de especies

human, mouse, rat

técnicas

flow cytometry: suitable (indirect)
immunocytochemistry: suitable
immunohistochemistry: suitable
western blot: suitable

Nº de acceso UniProt

temp. de almacenamiento

−20°C

modificación del objetivo postraduccional

unmodified

Información sobre el gen

human ... AQP4(361)
mouse ... Aqp4(11829)
rat ... Aqp4(25293)

Descripción general

AQP4 is an osmoreceptor that regulates water flow in the CNS. It is abundant in astrocytes, but is also weakly noticeable in pulmonary, intestinal, ocular and renal tissues. Rabbit Anti-Water Channel Aquaporin 4 antibody recognizes aquaporin 4 in human, mice and rats.

Inmunógeno

recombinant fusion protein corresponding to residues 249-323 of rat AQP4 fused to GST.

Aplicación

Rabbit Anti-Water Channel Aquaporin 4 antibody can be used for immunohistochemical applications. The antibody can also be used for immunocytochemistry, western blot and flow cytometry applications.

Acciones bioquímicas o fisiológicas

Immunoprecipation and western blot analysis using HEK-293 cells that had been transfected with GFP-AQP4 was performed using rabbit anti-AQP4 as the primary antibody at 2μl/ml.

Forma física

Lyophilized from phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin, and 0.05% sodium azide.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Opcional

Referencia del producto
Descripción
Precios

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable


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Gry Fluge Vindedal et al.
Molecular and cellular neurosciences, 77, 47-52 (2016-11-05)
There is a constitutive production of water in brain. The efflux routes of this excess water remain to be identified. We used basal brain water content as a proxy for the capacity of water exit routes. Basal brain water content
Paraneoplastic Neuromyelitis Optica Associated with Lung Adenocarcinoma in a Young Woman.
Kyoung Won Baik et al.
Journal of clinical neurology (Seoul, Korea), 14(2), 246-247 (2018-04-10)
Charles L Howe et al.
Glia, 62(5), 692-708 (2014-02-05)
Neuromyelitis optica (NMO) is a primary astrocyte disease associated with central nervous system inflammation, demyelination, and tissue injury. Brain lesions are frequently observed in regions enriched in expression of the aquaporin-4 (AQP4) water channel, an antigenic target of the NMO
Vanda A Lennon et al.
The Journal of experimental medicine, 202(4), 473-477 (2005-08-10)
Neuromyelitis optica (NMO) is an inflammatory demyelinating disease that selectively affects optic nerves and spinal cord. It is considered a severe variant of multiple sclerosis (MS), and frequently is misdiagnosed as MS, but prognosis and optimal treatments differ. A serum
Satoshi Tomura et al.
Journal of neurotrauma, 28(2), 237-243 (2010-11-19)
Decompressive craniectomy is one therapeutic option for severe traumatic brain injury (TBI), and it has long been used for the treatment of patients with malignant post-traumatic brain edema. A lack of definitive evidence, however, prevents physicians from drawing any conclusions

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