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94072

Sigma-Aldrich

Phalloidin–Atto 565

suitable for fluorescence, ≥80.0% (HPLC)

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About This Item

Código UNSPSC:
12352108
NACRES:
NA.32

Nivel de calidad

100

Ensayo

≥80.0% (HPLC)

Formulario

solid

mol peso

Mw 1394 g/mol

fabricante / nombre comercial

ATTO-TEC GmbH

λ

in methanol

Absorción UV

λ: 562.0-568.0 nm Amax

idoneidad

suitable for fluorescence

temp. de almacenamiento

−20°C

Descripción general

Atto 565 is a novel fluorescent label that belongs to the class of Rhodamine dyes. It shows a strong absorption, high fluorescence quantum yield, high thermal and photostability, and a very little triplet formation. Atto 565 consists of a mixture of two isomers with practically identical optical absorption and emission Phalloidin is a fungal toxin isolated from the poisonous mushroom Amanita phalloides. Its toxicity is attributed to the ability to bind F actin in liver and muscle cells. As a result of binding phalloidin, actin filaments become strongly stabilized. Phalloidin has been found to bind only to polymeric and oligomeric forms of actin, and not to monomeric actin. The dissociation constant of the actin-phalloidin complex has been determined to be on the order of 3 x 10-8. Phalloidin differs from amanitin in rapidity of action; at high dose levels, death of mice or rats occurs within 1 or 2 hours. Fluorescent conjugates of phalloidin are used to label actin filaments for histological applications. Some structural features of phalloidin are required for the binding to actin. However, the side chain of amino acid 7 (g-d-dihydroxyleucine) is accessible for chemical modifications without appreciable loss of affinity for actin.

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Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number
BCCM7766
BCCM0704
BCCL9537
BCCL7632
BCCL2805

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Atto 565 BioReagent, suitable for fluorescence

Sigma-Aldrich

75784

Atto 565

Aixin Cheng et al.
Tissue engineering. Part A, 24(11-12), 968-978 (2017-12-28)
We previously developed a 14-day culture protocol under potentially GMP, chemically defined conditions, to generate chondroprogenitors from human embryonic stem cells (hESCs). In vivo work has confirmed the cartilage repair capacity of these cells in a nude rat osteochondral defect
Silke Rothenbusch-Fender et al.
Biology open, 6(12), 1876-1888 (2017-11-11)
During
Mariangela Sabatella et al.
Cell reports, 34(2), 108608-108608 (2021-01-14)
Hereditary DNA repair defects affect tissues differently, suggesting that in vivo cells respond differently to DNA damage. Knowledge of the DNA damage response, however, is largely based on in vitro and cell culture studies, and it is currently unclear whether DNA repair
Sabine Galland et al.
Cancer letters, 484, 50-64 (2020-05-19)
Solid tumor growth triggers a dynamic host response, which recapitulates wound healing and defines the tumor microenvironment (TME). In addition to the action of the tumor cells themselves, the TME is maintained by a myriad of immune and stromal cell-derived
Preethi P et al.
Frontiers in immunology, 11, 1528-1528 (2020-08-28)
A large body of research implicates the brain and fat body (liver equivalent) as central players in coordinating growth and nutritional homeostasis in multicellular animals. In this regard, an underlying connection between immune cells and growth is also evident, although
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