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85580

SAFC

Spermidine trihydrochloride

≥99.0% (AT)

Sinónimos:

N-(3-Aminopropyl)-1,4-butanediamine trihydrochloride

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About This Item

Fórmula lineal:
NH2(CH2)3NH(CH2)4NH2 · 3HCl
Número de CAS:
334-50-9
Peso molecular:
254.63
Beilstein/REAXYS Number:
3552356
EC Number:
206-379-0
MDL number:
MFCD00012918
UNSPSC Code:
12352204
PubChem Substance ID:
329769390
NACRES:
NA.77

biological source

microbial
synthetic

assay

≥99.0% (AT)

form

powder

mp

~250 °C (dec.)
257-259 °C (lit.)

solubility

H2O: 0.1 g/mL, clear, colorless

storage temp.

room temp

SMILES string

Cl[H].Cl[H].Cl[H].NCCCCNCCCN

InChI

1S/C7H19N3.3ClH/c8-4-1-2-6-10-7-3-5-9;;;/h10H,1-9H2;3*1H

InChI key

LCNBIHVSOPXFMR-UHFFFAOYSA-N

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General description

Spermidine is a polyamine and a trivalent organic cation.

Application

Spermidine trihydrochloride has been used as standard for the detection of biogenic amines using HPLC.

Biochem/physiol Actions

Inhibits neuronal nitric oxide synthase (nNOS). Binds and precipitates DNA; may be used for purification of DNA binding proteins. Stimulates T4 polynucleotide kinase activity.
Spermidine modulates various cellular activities like cellular development and differentiation, stability of DNA and apoptosis.

Caution

Solutions should be sterile-filtered, not autoclaved, if sterile solution is necessary. Spermidine deaminates with time; solutions should be stored frozen. Prepare new solutions frequently.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H315,H319

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Koral S, et al.
Turkish Journal of Fisheries and Aquatic Sciences, 15(3), 495-504 (2015)
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Self-nonself discrimination is vital for the immune system to mount responses against pathogens while maintaining tolerance toward the host and innocuous commensals during homeostasis. Here, we investigated how indiscriminate DNA sensors, such as cyclic GMP-AMP synthase (cGAS), make this self-nonself
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