485A-1

ATRX Rabbit Polyclonal Antibody

• Sinónimos: ATP-dependent helicase ATRX, X-linked helicase II, X-linked nuclear protein (XNP)
• Código UNSPSC: 41116161

Propiedades

• origen biológico: rabbit blood
• Nivel de calidad: 100; 500
• conjugado: unconjugated
• forma del anticuerpo: IgG fraction of antiserum
• tipo de anticuerpo: primary antibodies
• descripción: For In Vitro Diagnostic Use in Select Regions
• Formulario: buffered aqueous solution
• reactividad de especies: human
• envase: vial of 0.1 mL (concentrate (485A-14)); vial of 0.1 mL (concentrate (485A-14-RUO) Research Use Only); vial of 0.5 mL (concentrate (485A-15)); vial of 1.0 mL (concentrate (485A-16)); vial of 1.0 mL (concentrate (485A-16-RUO) Research Use Only); vial of 1.0 mL (concentrate (485A-17-RUO) Research Use Only); vial of 1.0 mL (pre-dilute ready-to-use (485A-17)); vial of 7.0 mL (concentrate (485A-18-RUO) Research Use Only); vial of 7.0 mL (pre-dilute ready-to-use (485A-18))
• fabricante / nombre comercial: Cell Marque^®
• técnicas: immunocytochemistry: suitable (formalin-fixed, paraffin-embedded sections 1:50-1:50 (concentrated))
• isotipo: IgG
• control: astrocytoma, brain, glioblastoma, oligodendroglioma
• Condiciones de envío: wet ice
• temp. de almacenamiento: 2-8°C
• visualización: nuclear

Descripción

Descripción general

Diffuse gliomas are classified based on histological and molecular features to achieve an integrated diagnosis. Molecular diagnostic markers include IDH mutation, 1p/19q co-deletion, and TP53 mutation. ATRX is a chromatin remodeling protein and its mutation status may be used as a molecular diagnostic marker within the diff use glioma classification algorithm. Anti-ATRX is used to identify mutant ATRX by a loss of ATRX expression in neoplastic cells when compared with internal positive controls (endothelial cells, glia, and neurons). Grade II/III astrocytoma classification includes IDH mutant, ATRX mutant, and 1p/19q retention, while grade II/III oligodendroglioma includes IDH mutant, ATRX wildtype, and 1p/19q co-deletion; p53 expression may also serve as an aid in diagnosis. ATRX mutation is frequently, but not always, mutually exclusive with 1p/19q co-deletion.

Calidad

United States - IVD
Canada - RUO
European Union - IVD
Japan - RUO

Forma física

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Nota de preparación

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Otras notas

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Información legal

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 12 - Non Combustible Liquids
• Clase de riesgo para el agua (WGK): WGK 2