PHR2589

5-Fluoro-2′-desoxiuridina

pharmaceutical secondary standard, certified reference material

• Sinónimos: 2′-Desoxi-5-fluorouridina, FUDR, Floxuridina
• Fórmula empírica (notación de Hill): C₉H₁₁FN₂O₅
• Número de CAS: 50-91-9
• Peso molecular: 246.19
• Beilstein/REAXYS Number: 90221
• MDL number: MFCD00006530
• UNSPSC Code: 41116107
• NACRES: NA.24

Propiedades

• grade: certified reference material; pharmaceutical secondary standard
• Quality Level: 300
• agency: traceable to USP 1271008
• description: Pharmaceutical Secondary Standard; Certified Reference Material
• API family: floxuridine
• form: powder
• CofA: current certificate can be downloaded
• packaging: pkg of 500 mg
• mp: 148 °C (lit.)
• application(s): pharmaceutical small molecule
• storage temp.: 2-30°C
• SMILES string: OC[C@H]1O[C@H](C[C@@H]1O)N2C=C(F)C(=O)NC2=O
• InChI: 1S/C9H11FN2O5/c10-4-2-12(9(16)11-8(4)15)7-1-5(14)6(3-13)17-7/h2,5-7,13-14H,1,3H2,(H,11,15,16)/t5-,6+,7+/m0/s1
• InChI key: ODKNJVUHOIMIIZ-RRKCRQDMSA-N

Descripción

General description

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem/physiol Actions

Antineoplásico que actúa como potente inhibidor de la timidilato sintetasa Puede desarrollarse resistencia a la FUdR en cultivos de células cancerosas, entre otros medios mediante la infección de bajo nivel con micoplasmas.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Información de seguridad

• pictograms: GHS06
• signalword: Danger
• hcodes: H301
• pcodes: P264 - P270 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 3 Oral
• Storage Class: 6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
• wgk_germany: WGK 3