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Merck

PHR1804

Supelco

Paroxetine hydrochloride

Pharmaceutical Secondary Standard; Certified Reference Material

Sinónimos:

Paroxetine hydrochloride hemihydrate, (3S-trans)-3-[(1,3-Benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)piperidine hydrochloride hemihydrate

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About This Item

Fórmula empírica (notación de Hill):
C19H20FNO3 · HCl · .5 H2O
Número de CAS:
Peso molecular:
374.83
Número MDL:
Código UNSPSC:
41116107
ID de la sustancia en PubChem:
NACRES:
NA.24

grado

certified reference material
pharmaceutical secondary standard

Nivel de calidad

Agency

traceable to BP 1024
traceable to Ph. Eur. Y0000281
traceable to USP 1500218

familia API

paroxetine

CofA

current certificate can be downloaded

envase

pkg of 500 mg

técnicas

HPLC: suitable
gas chromatography (GC): suitable

aplicaciones

pharmaceutical (small molecule)

Formato

neat

temp. de almacenamiento

2-8°C

cadena SMILES

O.Cl[H].Fc1ccc(cc1)[C@@H]2CCNC[C@H]2COc3ccc4OCOc4c3

InChI

1S/C19H20FNO3.ClH.H2O/c20-15-3-1-13(2-4-15)17-7-8-21-10-14(17)11-22-16-5-6-18-19(9-16)24-12-23-18;;/h1-6,9,14,17,21H,7-8,10-12H2;1H;1H2/t14-,17-;;/m0../s1

Clave InChI

QRQSGFFISBKLMZ-YHOFXEKLSA-N

Información sobre el gen

human ... SLC6A4(6532)

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Descripción general

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Paroxetine hydrochloride, a phenylpiperidine derivative, is a selective serotonin reuptake inhibitor (SSRI) used for its anti-depressant properties. It is used to treat major depression, post-traumatic stress disorder (PTSD), panic disorder, and obsessive-compulsive disorder (OCD) among others.

Aplicación

This pharmaceutical secondary standard can also be used as follows:

  • Development of a reversed phase high-performance liquid chromatographic (RP-HPLC) method for the determination of paroxetine and clonazepam in pharmaceutical tablet forms
  • High-performance thin-layer chromatographic (HPTLC) determination of paroxetine and clonazepam in pharmaceutical formulations following International Conference on Harmonization (ICH) guidelines
  • Chiral and achiral impurity profiling of paroxetine hydrochloride using supercritical fluid chromatography (SFC) and a chiral stationary phase
  • Determination of seven phosphodiesterase-5 inhibitors and serotonin reuptake inhibitors by HPLC combined with diode array detection (DAD) from tablet dosage forms
  • Separation and estimation of paroxetine from its enantiomeric and diastereomeric impurities by an HPLC method using an amylose-based chiral stationary phase

Acciones bioquímicas o fisiológicas

Paroxetine hydrochloride hemihydrate is one of the most potent and selective of the selective serotonin reuptake inhibitors (SSRI); antidepressant
Selective serotonin reuptake inhibitor; antidepressant

Nota de análisis

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Nota al pie de página

To see an example of a Certificate of Analysis for this material enter LRAB7850 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

Producto relacionado

Referencia del producto
Descripción
Precios

Pictogramas

Exclamation markEnvironment

Palabra de señalización

Warning

Frases de peligro

Clasificaciones de peligro

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Sens. 1 - STOT SE 3

Órganos de actuación

Respiratory system

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable


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Visite la Librería de documentos

Kateryna Murlanova et al.
Journal of affective disorders, 282, 1055-1066 (2021-02-20)
Dominant-submissive relationships depend upon functionality of the neural circuits involving monoaminergic neurotransmission. Behavioral profiles of selectively bred dominant (Dom) and submissive (Sub) mice have been proposed to mimic hyperthymic- or depressive-like temperaments observed in patients with affective disorders. These mice
Micellar high performance liquid chromatographic method for simultaneous determination of clonazepam and paroxetine HCl in pharmaceutical preparations using monolithic column
Ibrahim F, et al.
Journal of Chromatography and Separation Techniques, 7, 2-2 (2016)
Development and validation of an HPTLC method for the simultaneous estimation of Clonazepam and Paroxetine hydrochloride using a DOE approach
Shah P, et al.
Journal of Taibah University for Science , 11, 121-132 (2017)
Jiyoung Lee et al.
Nature, 568(7751), 254-258 (2019-03-08)
Mitochondrial metabolism is an attractive target for cancer therapy1,2. Reprogramming metabolic pathways could improve the ability of metabolic inhibitors to suppress cancers with limited treatment options, such as triple-negative breast cancer (TNBC)1,3. Here we show that BTB and CNC homology1

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