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PHR1061

Supelco

Valproic acid

Pharmaceutical Secondary Standard; Certified Reference Material

Sinónimos:

2-Propylpentanoic acid, 2-Propylvaleric acid, Valproic acid

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About This Item

Fórmula lineal:
(CH3CH2CH2)2CHCO2H
Número de CAS:
99-66-1
Peso molecular:
144.21
Número CE:
202-777-3
Número MDL:
MFCD00002672
Código UNSPSC:
41116107
ID de la sustancia en PubChem:
329823091
NACRES:
NA.24
En este momento no podemos mostrarle ni los precios ni la disponibilidad

grado

certified reference material
pharmaceutical secondary standard

Nivel de calidad

300

Agency

traceable to Ph. Eur. V0033000
traceable to USP 1708707

familia API

valproic acid

CofA

current certificate can be downloaded

técnicas

HPLC: suitable
gas chromatography (GC): suitable

índice de refracción

n20/D 1.425 (lit.)

bp

220 °C (lit.)

densidad

0.9 g/mL at 25 °C (lit.)

aplicaciones

pharmaceutical (small molecule)

Formato

neat

temp. de almacenamiento

2-30°C

cadena SMILES

CCCC(C(O)=O)CCC

InChI

1S/C8H16O2/c1-3-5-7(6-4-2)8(9)10/h7H,3-6H2,1-2H3,(H,9,10)

Clave InChI

NIJJYAXOARWZEE-UHFFFAOYSA-N

Información sobre el gen

human ... ALDH5A1(7915)

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Descripción general

Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to in-house working standards.
It is widely used in the treatment of bipolar disorder, migraine, depression, epilepsy and schizophrenia.[1]
Valproic acid is a branched short chain fatty acid, which finds applications as a antiepileptic drug.[2][3]

Aplicación

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Valproic acid may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations using gas chromatography technique.[1]

Acciones bioquímicas o fisiológicas

Anticonvulsant that also has efficacy as a mood stabilizer in bipolar disorder

Nota de análisis

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Otras notas

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Nota al pie de página

To see an example of a Certificate of Analysis for this material enter LRAB3712 in the slot below. This is an example certificate only and may not be the lot that you receive.

Productos recomendados

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Palabra de señalización

Danger

Frases de peligro

H302,H315,H318,H360FD

Clasificaciones de peligro

Acute Tox. 4 Oral - Eye Dam. 1 - Repr. 1A - Skin Irrit. 2

Código de clase de almacenamiento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

231.8 °F - closed cup

Punto de inflamabilidad (°C)

111 °C - closed cup

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Certificados de análisis (COA)

Lot/Batch Number

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Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen
Phiel JC, et al.
The Journal of Biological Chemistry, 276(39), 36734-36741 (2001)
Inhibition of microsomal Phenobarbital metabolism by valproic acid
Kapetanovic MI and Kupferberg JH
Biochemical Pharmacology, 30(11), 1361-1363 (1981)
Headspace solid-phase microextraction-gas chromatography method for the determination of valproic acid in human serum, and formulations using hollow-fiber coated wire
Farajzadeh AM, et al.
Analytical Sciences, 25(7), 875-879 (2009)
Jiajun Zhou et al.
Journal of cellular and molecular medicine, 24(15), 8636-8649 (2020-07-01)
Chronic renal failure (CRF) is commonly associated with various adverse consequences including pathological vascular calcification (VC), which represents a significant clinical concern. Existing literature has suggested the involvement of histone deacetylases (HDACs) in the progression of CRF-induced VC. However, the
P C Ho et al.
The pharmacogenomics journal, 3(6), 335-342 (2003-11-05)
The present study investigated the effect of cytochrome P450 2C9 (CYP2C9) genetic polymorphism on the biotransformation of valproic acid (VPA) to its hepatotoxic metabolite, 4-ene-VPA, and compared that to the formation of the inactive 4-OH-VPA and 5-OH-VPA. cDNA-expressed CYP2C9(*)2 and
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Questions

1–2 of 2 Questions  

  1. Could you please provide me with information regarding the solvent used to dissolve this product and the final concentration of valproic acid in 1G pack (as g/ml) Additionally, I would like to know if valproic acid available for purchase in powder form

    1 answer

    1. In the pure form, Valproic acid exists as a neat liquid, the concentration will be considered 100%. The density of the pure form is 0.905 g/mL at 20 °C. The solubility is not tested, however literature shows that it is only slightly soluble in water - 1.3 - 2.0 mg/mL. It is freely soluble in organic solvents, acids and bases. The salt forms are available as powders. Please see the links below to review additional solubility information available at PubChem, as well as a link to the powder form of this product.

      PubChem - see section 3:
      https://pubchem.ncbi.nlm.nih.gov/compound/Valproic-Acid#section=Solubility

      Valproic acid sodium salt:
      https://www.sigmaaldrich.com/US/en/product/sigma/p4543

      Helpful?

  2. Is it necessary to dissolve in any solvent (like water or serum physiologic) for administration to rats intraperitoneally. Or can it be applied directly?

    1 answer

    1. Valproic acid is reportedly water soluble at 50 mg/mL. However, this product has not been tested for in vivo or in vitro use. This product is not sterile, suitability would have to be determined by the end-user.

      Helpful?

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