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N0020000

Nabumetone

European Pharmacopoeia (EP) Reference Standard

Sinónimos:

4-(6-Methoxy-2-naphthyl)-2-butanone

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About This Item

Fórmula empírica (notación de Hill):
C15H16O2
Número de CAS:
42924-53-8
Peso molecular:
228.29
Número MDL:
MFCD00079518
Código UNSPSC:
41116107
ID de la sustancia en PubChem:
329818390
NACRES:
NA.24

grado

pharmaceutical primary standard

familia API

nabumetone

fabricante / nombre comercial

EDQM

aplicaciones

pharmaceutical (small molecule)

Formato

neat

cadena SMILES

COc1ccc2cc(CCC(C)=O)ccc2c1

InChI

1S/C15H16O2/c1-11(16)3-4-12-5-6-14-10-15(17-2)8-7-13(14)9-12/h5-10H,3-4H2,1-2H3

Clave InChI

BLXXJMDCKKHMKV-UHFFFAOYSA-N

Información sobre el gen

human ... PTGS2(5743)

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Descripción general

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Aplicación

Nabumetone EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Acciones bioquímicas o fisiológicas

Nonselective non-steroidal anti-inflammatory drug (NSAID)

Envase

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Otras notas

Sales restrictions may apply.

Producto relacionado

Referencia del producto
Descripción
Precios

N0020020

Nabumetone impurity D, European Pharmacopoeia (EP) Reference Standard

N0020030

Nabumetone impurity F, European Pharmacopoeia (EP) Reference Standard

1449518

Nabumetone, United States Pharmacopeia (USP) Reference Standard

1449530

Nabumetone Related Compound A, United States Pharmacopeia (USP) Reference Standard

08137

2-(6-Methoxynaphthalen-2-yl)acetic acid, pharmaceutical impurity standard

BP358

Nabumetone, British Pharmacopoeia (BP) Reference Standard

BP851

Nabumetone impurity D, British Pharmacopoeia (BP) Reference Standard

PHR3056

Nabumetone, pharmaceutical secondary standard, certified reference material

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 2

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number

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Michael Crothers et al.
International journal of pharmaceutics, 358(1-2), 303-306 (2008-04-18)
The solubilisation of two poorly soluble drugs, furosemide and nabumetone, in micellar solutions of diblock copolymers of ethylene oxide and styrene oxide has been studied at 25 and 37 degrees C and solubilisation capacities compared with published values for griseofulvin
Solubility of triamcinolone acetonide and other anti-inflammatory drugs in silicone oil: implications for Therapeutic Efficacy.
José Carlos Pastor et al.
Retina (Philadelphia, Pa.), 28(9), 1247-1250 (2008-07-17)
Kaori Matsumoto et al.
Biological & pharmaceutical bulletin, 34(5), 734-739 (2011-05-03)
The cytochrome P450 (CYP) isoforms that catalyze the oxidation metabolism of 6-methoxy-2-napthylacetic acid (6-MNA), an active metabolite of nabumetone, were studied in rats and humans. Using an extractive reversed-phase HPLC assay with fluorescence detection, monophasic Michaelis-Menten kinetics was obtained for
Jinhyun Kim et al.
Clinical therapeutics, 31(12), 2860-2872 (2010-01-30)
S-adenosylmethionine (SAMe) has antiinflammatory and analgesic effects and has been reported to ameliorate the pain and dysfunction of osteoarthritis (OA). The metabolism of SAMe can be affected by geographic or ethnic factors. However, its efficacy and tolerability versus NSAIDs have
Nao Setoguchi et al.
Biopharmaceutics & drug disposition, 34(2), 125-136 (2012-12-12)
Diclofenac suppository, a non-steroidal anti-inflammatory drug (NSAID), is used widely in rheumatoid arthritis (RA) patients with severe arthritic pain. As the binding percentage of diclofenac to serum proteins is high, its free (unbound) concentration after rectal administration is low. To
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