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E2150000

Ethosuximide

European Pharmacopoeia (EP) Reference Standard

Sinónimos:

2-Ethyl-2-methylsuccinimide

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About This Item

Fórmula empírica (notación de Hill):
C7H11NO2
Número de CAS:
77-67-8
Peso molecular:
141.17
MDL number:
MFCD00072123
UNSPSC Code:
41116107
PubChem Substance ID:
329799026
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

ethosuximide

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

O=C1NC(CC1(C)CC)=O

InChI

1S/C7H11NO2/c1-3-7(2)4-5(9)8-6(7)10/h3-4H2,1-2H3,(H,8,9,10)

InChI key

HAPOVYFOVVWLRS-UHFFFAOYSA-N

Gene Information

human ... CACNA1G(8913) , CACNA1H(8912) , CACNA1I(8911)

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Ethosuximide EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number

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S J Wallace
Epilepsy research, 29(2), 147-154 (1998-02-26)
Based on small numbers of patients, it is possible to make the following suggestions rather than categorical statements. For myoclonic seizures and epilepsies which are not otherwise specified, valproate seems of proven efficacy. Ethosuximide may be a useful adjunct. The
J S Millership et al.
European journal of drug metabolism and pharmacokinetics, 18(4), 349-353 (1993-10-01)
The metabolism of the antiepileptic drug ethosuximide (3-ethyl-3-methylpyrollidine-2,5-dione) (I) in animals and humans is reviewed. Chiral aspects of the metabolism of ethosuximide are discussed. Clarification of the precise nature of the hydroxymetabolites of ethosuximide is presented.
[Ethosuximide].
M Ichiba et al.
Nihon rinsho. Japanese journal of clinical medicine, 53 Su Pt 1, 915-917 (1995-02-01)
Sloka S Iyengar et al.
Experimental neurology, 264, 135-149 (2014-12-06)
Adult neurogenesis, the generation of new neurons in the adult brain, occurs in the hippocampal dentate gyrus (DG) and the olfactory bulb (OB) of all mammals, but the functions of these new neurons are not entirely clear. Originally, adult-born neurons
Ewa B Posner et al.
Seizure, 14(2), 117-122 (2005-02-08)
To evaluate the role of ethosuximide, sodium valproate and lamotrigine in children and adolescents with typical absence seizures (AS). A systematic review of randomized controlled trials that included children or adolescents with typical absence seizures who received treatment with ethosuximide
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