BP227

1,1-Dimetilbiguanida hydrochloride

British Pharmacopoeia (BP) Reference Standard

• Sinónimos: Metformina
• Fórmula lineal: NH₂C(=NH)NHC(=NH)N(CH₃)₂ · HCl
• Número de CAS: 1115-70-4
• Peso molecular: 165.62
• EC Number: 214-230-6
• MDL number: MFCD00012582
• UNSPSC Code: 41116107
• NACRES: NA.24

Propiedades

• grade: pharmaceutical primary standard
• API family: metformin
• form: crystalline
• shelf life: limited shelf life, expiry date on the label
• manufacturer/tradename: BP
• mp: 223-226 °C (lit.)
• application(s): pharmaceutical; pharmaceutical small molecule
• format: neat
• storage temp.: 2-8°C
• SMILES string: Cl[H].CN(C)C(=N)NC(N)=N
• InChI: 1S/C4H11N5.ClH/c1-9(2)4(7)8-3(5)6;/h1-2H3,(H5,5,6,7,8);1H
• InChI key: OETHQSJEHLVLGH-UHFFFAOYSA-N

Descripción

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Metformin hydrochloride BP Reference standard, intended for use in laboratory tests only as specifically prescribed in the British Pharmacopoeia.

Also used in monographs such as:

Metformin Tablets

Metformin Oral Solution

Metformin and Sitagliptin Prolonged-release Tablets

Metformin Prolonged-release Tablets

Metformin and Sitagliptin Tablets

Biochem/physiol Actions

La metformina es un antidiabético que reduce las concentraciones de glucosa en sangre y mejora la sensibilidad a la insulina. Sus efectos metabólicos, entre ellos la inhibición de la gluconeogénesis hepática, están mediados al menos en parte por la activación de la ruta LKB1-AMPK (proteína cinasa activada por AMP). La activación de esta vía también parece estar implicada en las acciones antiproliferativas y proapoptóticas de la metformina en las líneas de células cancerosas.

Packaging

Unit quantity: 100 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity please visit British Pharmacopoeia

Other Notes

Sales restrictions may apply.

Información de seguridad

• pictograms: GHS07
• signalword: Warning
• hcodes: H302,H319
• pcodes: P264 - P280 - P301 + P312 - P305 + P351 + P338 - P337 + P313 - P501
• Hazard Classifications: Acute Tox. 4 Oral - Eye Irrit. 2
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable