8.55130

Rink Amide AM resin (100-200 mesh)

Novabiochem^®

• Sinónimos: Rink Amide AM resin (100-200 mesh), 4-(2′,4′-Dimethoxyphenyl-Fmoc-aminomethyl)-phenoxyacetamido-aminomethyl resin
• Número de CAS: 183599-10-2
• UNSPSC Code: 12352111
• NACRES: NA.22

Propiedades

• Quality Level: 400
• product line: Novabiochem^®
• form: powder
• reaction suitability: reaction type: Fmoc solid-phase peptide synthesis
• manufacturer/tradename: Novabiochem^®
• application(s): peptide synthesis
• functional group: amine
• storage temp.: 2-30°C

Descripción

General description

This support comprises the modified Rink amide linker attached to aminomethylpolystyrene and is an ideal tool for the Fmoc SPPS of peptide amides. Cleavage from this resin can be effected by a single step treatment with 95% TFA, providing peptide amides in high yields and purities.

Associated Protocols and Technical Articles
Protocols for Loading of Peptide Synthesis Resins

Application

Applications of Rink Amide AM resin (100-200 mesh)in solid phase organic synthesis include:

• In the synthesis of quinazolinone derivatives via intramolecular transamidation.
• In the preparation of 2-aminoquinazoline-based compounds using solid-phase peptide synthesis (SPPS) methodology.
• For the synthesis of α-aryl ketones via a palladium-catalyzed coupling reaction.

Legal Information

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable