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662105

Sigma-Aldrich

Ubiquitin E1 Inhibitor, PYR-41

The Ubiquitin E1 Inhibitor, PYR-41 controls the biological activity of Ubiquitin E1. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

Sinónimos:

Ubiquitin E1 Inhibitor, PYR-41, 4-(4-(5-Nitro-furan-2-ylmethylene)-3,5-dioxo-pyrazolidin-1-yl)-benzoic acid ethyl ester, trihydrate, Ubiquitin-Activating Enzyme E1 Inhibitor, PYR-41

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About This Item

Fórmula empírica (notación de Hill):
C17H13N3O7 · 3H2O
Peso molecular:
425.35
Código UNSPSC:
12352200
NACRES:
NA.77

Nivel de calidad

100

Ensayo

≥90% (sum of two isomers, HPLC)

Formulario

solid

fabricante / nombre comercial

Calbiochem®

condiciones de almacenamiento

OK to freeze
protect from light

color

dark purple

solubilidad

DMSO: 10 mg/mL

Condiciones de envío

wet ice

temp. de almacenamiento

−20°C

Descripción general

A cell-permeable pyrazone compound that irreversibly (presumably via covalent modification) inhibits ubiquitin-activating enzyme E1 activity (IC50<10 µM in cell-free E1 ubiquitination reactions), while exhibiting little or no activity against E3, E2, or caspase enzymatic activity. Blocks ubiquitination-dependent protein degradation and other ubiquitination-mediated cellular activities. E1 inactivation by PYR-41 or other means has been shown to result in an overall elevation of sumoylation.

Envase

Packaged under inert gas

Advertencia

Toxicity: Irritant (B)

Reconstitución

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C. At room temperature, compound will undergo ~1% decomposition per day.

Otras notas

Yang, Y., et al. 2007. Cancer Res.67, 9472.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 1

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Subhash Mehto et al.
The EMBO journal, 41(23), e111289-e111289 (2022-10-13)
The NOD1/2-RIPK2 is a key cytosolic signaling complex that activates NF-κB pro-inflammatory response against invading pathogens. However, uncontrolled NF-κB signaling can cause tissue damage leading to chronic diseases. The mechanisms by which the NODs-RIPK2-NF-κB innate immune axis is activated and

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