539165

Proteasome Inhibitor Set II

The Proteasome Inhibitor Set II controls the biological activity of Proteasome. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

• Código UNSPSC: 12352200
• NACRES: NA.77

Propiedades

• Nivel de calidad: 100
• Formulario: solid
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze; protect from light
• Condiciones de envío: ambient
• temp. de almacenamiento: −20°C

Descripción

Descripción general

Contains 5 mg of ALLN (Cat. No. 208719), 100 μg each of Epoxomicin (Cat. No. 324800), and clasto-Lactacystin β-Lactone (Cat. No. 426102). Supplied with a data sheet.

Proteasomes are large multi-subunit protease complexes, which selectively degrade intracellular proteins. A protein marked for degradation is attached to multiple molecules of ubiquitin, a 76-amino acid protein, which escorts it for rapid hydrolysis, by the 26S proteasome. The proteolytic core of this complex consists of the 20S proteasome, which contains multiple peptidase activities and has a molecular mass of ~700 kDa. Recently several potent, cell-permeable proteasome inhibitors have been developed.



The Calbiochem brand offers a set that includes 3 proteasome inhibitors with varying inhibtory effects.



The table below outlines some of the physical and biological properties of these compounds.

Acciones bioquímicas o fisiológicas

Primary Target
calpain 1, calpain 2

Secondary Target
cathepsin B, cathepsin L

Envase

Packaged under inert gas

Advertencia

Toxicity: Standard Handling (A)

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids