371724

GPR119 Agonist, AS1269574

The GPR119 Agonist, AS1269574, also referenced under CAS 330981-72-1, controls the biological activity of GPR119. This small molecule/inhibitor is primarily used for Biochemicals applications.

• Sinónimos: GPR119 Agonist, AS1269574, 2-((2-(4-Bromophenyl)-6-methylpyrimidin-4-yl)amino)ethanol, G-Protein Coupled Receptor 119 Agonist, GPCR2 Agonist, MGC119957 Agonist, SNORF25 Agonist, GPCR2 Agonist, MGC119957 Agonist, SNORF25 Agonist, 2-((2-(4-Bromophenyl)-6-methylpyrimidin-4-yl)amino)ethanol, G-Protein Coupled Receptor 119 Agonist
• Fórmula empírica (notación de Hill): C₁₃H₁₄BrN₃O
• Número de CAS: 330981-72-1
• Peso molecular: 308.17
• MDL number: MFCD00298280
• UNSPSC Code: 51111800
• NACRES: NA.51

Propiedades

• Quality Level: 100
• assay: ≥99% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: amber
• solubility: DMSO: >10 mg/mL
• shipped in: ambient
• storage temp.: 2-8°C
• SMILES string: BrC(C=C1)=CC=C1C2=NC(C)=CC(NCCO)=N2
• InChI: 1S/C13H14BrN3O/c1-9-8-12(15-6-7-18)17-13(16-9)10-2-4-11(14)5-3-10/h2-5,8,18H,6-7H2,1H3,(H,15,16,17)
• InChI key: DUKPGOOUJNUIOI-UHFFFAOYSA-N

Descripción

General description

A pyrimidine compound that acts as an effective GPR119 agonist (EC₅₀ = 2.5 µM in stimulating cAMP in hGPR119-expressing HEK293 cells) and reportedly exhibits no activity toward β-adrenergic or GLP-1 receptors. Shown to enhance 16.8 mM glucose-induced insulin secretion from murine MIN-6 β-cells (mU/20 min = 0.22, 0.29, 0.44, respectively, with 0, 1, 10 µM AS1269574) in vitro and improve glucose tolerance in normal mice (26% decrease and 60% increase, respectively, of control blood glucose and insulin AUC_0-1h in OGTT; 100 mg/kg; p.o.) without affecting basal blood glucose level in either fed or fasting mice in vivo.

A pyrimidine compound that acts as an effective GPR119 agonist (EC₅₀ = 2.5 µM in stimulating cAMP in hGPR119-expressing HEK293 cells) and reportedly exhibits no activity toward β-adrenergic or GLP-1 receptors. Shown to enhance 16.8 mM glucose-induced insulin secretion from murine MIN-6 β-cells (mU/20 min = 0.44 and 0.22, respectively, with or without 10 µM AS1269574) in vitro and improve glucose tolerance in normal mice (100 mg/kg; p.o.) without any significant hypoglycemic effect in vivo.

Packaging

Packaged under inert gas

Warning

Toxicity: Regulatory Review (Z)

Other Notes

Yoshida, S., et cl. 2010. Biochem. Biophys. Res. Commun.400, 437.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable