07-1800
Anti-eIF4G Antibody
serum, from rabbit
Sinónimos:
eIF-4-gamma 1, eIF-4G 1, eukaryotic translation initiation factor 4 gamma 1
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About This Item
Código UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41
origen biológico
rabbit
Nivel de calidad
forma del anticuerpo
serum
tipo de anticuerpo
primary antibodies
clon
polyclonal
reactividad de especies
human, mouse
técnicas
immunofluorescence: suitable
western blot: suitable
Nº de acceso NCBI
Nº de acceso UniProt
Condiciones de envío
wet ice
modificación del objetivo postraduccional
unmodified
Información sobre el gen
human ... EIF4G1(1981)
Descripción general
eIF4F is a translation initiation factor containing three subunits: eIF4A, eIF4E, and eIF4G. This complex is a key component in promoting ribosomal binding to the mRNA. eIF4G interacts with both eIF4A and eIF4E though its carboxy and amino terminal domains, respectively. eIF4E binds to the cap structure of the mRNA, while the ATP-dependent RNA helicase eIF4A unwinds the secondary structure of the 5’ UTR. eIF4G plays a critical role in coordinating the assembly of the eukaryotic initiation factors. It acts as a bridge to bind the cap-bound eIF4E, eIF4AI&II, the eIF3 complex, PABP1, and the kinase Mnk1 (Lejeune, F., et al., 2004) in a large eukaryotic initiation factor complex
Especificidad
Not tested on other species.
This antibody detects eIF4G at its N-terminal region.
Inmunógeno
Epitope: N-terminus
Synthetic peptide corresponding to N-terminal region of human eIF4G.
Aplicación
Anti-eIF4G Antibody is an antibody against eIF4G for use in WB & IF.
Research Category
Signaling
Signaling
Research Sub Category
RNA Binding Protein (RBP)
Insulin/Energy Signaling
RNA Binding Protein (RBP)
Insulin/Energy Signaling
Calidad
Evaluated by western blot on HeLa cytoplasmic extract.
Western Blot Analysis: 1:1,000 dilution of this antibody was used to detect eIF4G in HeLa cytoplasmic extract and lysates from 293T and S10 cells.
Western Blot Analysis: 1:1,000 dilution of this antibody was used to detect eIF4G in HeLa cytoplasmic extract and lysates from 293T and S10 cells.
Descripción de destino
220 kDa
Forma física
Rabbit polyclonal serum with 0.05% NaN3.
Almacenamiento y estabilidad
Stable for 1 year at -20ºC from date of receipt.
Cláusula de descargo de responsabilidad
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Código de clase de almacenamiento
10 - Combustible liquids
Certificados de análisis (COA)
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American journal of physiology. Endocrinology and metabolism, 320(3), E551-E565 (2021-01-12)
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Daniel A Columbus et al.
American journal of physiology. Endocrinology and metabolism, 309(6), E601-E610 (2015-09-17)
Most low-birth weight infants experience extrauterine growth failure due to reduced nutrient intake as a result of feeding intolerance. The objective of this study was to determine whether prolonged enteral leucine supplementation improves lean growth in neonatal pigs fed a
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American journal of physiology. Endocrinology and metabolism, 321(6), E737-E752 (2021-11-02)
Optimizing enteral nutrition for premature infants may help mitigate extrauterine growth restriction and adverse chronic health outcomes. Previously, we showed in neonatal pigs born at term that lean growth is enhanced by intermittent bolus compared with continuous feeding. The objective
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Postnatal growth failure in premature infants is associated with reduced lean mass accretion. Prematurity impairs the feeding-induced stimulation of translation initiation and protein synthesis in the skeletal muscle of neonatal pigs. The objective was to determine whether body weight independently
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