702757

Potassium tert-pentoxide solution

2 M in THF

• Sinónimos: Potassium tert-amylate, Potassium (2-methyl-2-butoxide), Potassium tert-pentylate
• Fórmula lineal: CH₃CH₂C(CH₃)₂OK
• Número de CAS: 41233-93-6
• Peso molecular: 126.24
• Beilstein: 4149025
• Número MDL: MFCD00064808
• Código UNSPSC: 12352001
• ID de la sustancia en PubChem: 329762401
• NACRES: NA.22

Propiedades

• Formulario: liquid
• Nivel de calidad: 100
• concentración: 2 M in THF
• densidad: 0.920 g/mL at 25 °C
• cadena SMILES: [K+].CCC(C)(C)[O-]
• InChI: 1S/C5H11O.K/c1-4-5(2,3)6;/h4H2,1-3H3;/q-1;+1
• Clave InChI: ZRLVQFQTCMUIRM-UHFFFAOYSA-N

Descripción

Descripción general

Potassiumtert-pentoxide solution is a strong and sterically hindered alkoxide baseprepared by treating oil-free potassium hydride with anhydrous t-pentylalcohol in anhydrous solvent.

Aplicación

Potassium tert-pentoxide solution can be used as a base in the:

• Wittig reaction of ketoesters with methyltriphenylphosphonium bromide to synthesize alkenes.
• Palladium-catalyzed Buchwald-Hartwig amination reaction.

It can also be used:

• To prepare potassium tert-pentoxide-crown ether complexes, which is used as a Lewis base catalyst in Mukaiyama aldol reaction.
• As an activator for (difluoromethyl)trimethylsilane to generate difluoromethyl-carbanion which reacts with isothiocyanate to synthesize α, α-difluoromethyl thioamide.

Características y beneficios

In the absence of air and moisture, potassium tert-pentoxide solutions in benzene or toluene may be stored in a refrigerator for up to 1 year without significant deterioration.

Información de seguridad

• Pictogramas: GHS02,GHS08,GHS05,GHS07
• Palabra de señalización: Danger
• Frases de peligro: H225,H302,H314,H335,H336,H351
• Consejos de prudencia: P210 - P280 - P301 + P312 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Clasificaciones de peligro: Acute Tox. 4 Oral - Carc. 2 - Eye Dam. 1 - Flam. Liq. 2 - Skin Corr. 1B - STOT SE 3
• Órganos de actuación: Central nervous system, Respiratory system
• Riesgos supl.: EUH019
• Código de clase de almacenamiento: 3 - Flammable liquids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): 1.4 °F - Solvent
• Punto de inflamabilidad (°C): -17 °C - Solvent
• Equipo de protección personal: Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter