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Key Documents

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205494

Sigma-Aldrich

Dibutyltin dichloride

96%

Sinónimos:

Dibutyldichlorotin

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About This Item

Fórmula lineal:
(CH3CH2CH2CH2)2SnCl2
Número de CAS:
683-18-1
Peso molecular:
303.84
Beilstein/REAXYS Number:
3535484
EC Number:
211-670-0
MDL number:
MFCD00000518
UNSPSC Code:
12352103
PubChem Substance ID:
24852336
NACRES:
NA.22

assay

96%

form

solid

bp

135 °C/10 mmHg (lit.)

mp

37-40 °C (lit.)

SMILES string

CCCC[Sn](Cl)(Cl)CCCC

InChI

1S/2C4H9.2ClH.Sn/c2*1-3-4-2;;;/h2*1,3-4H2,2H3;2*1H;/q;;;;+2/p-2

InChI key

RJGHQTVXGKYATR-UHFFFAOYSA-L

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Application

  • Effects of dibutyltin compounds on PPARγ/RXRα activity: Studies the impact of various dibutyltin compounds, including dibutyltin dichloride, on adipogenesis and inflammation in mammalian cells, emphasizing their effects on the PPARγ/RXRα pathway (Milton et al., 2017).

signalword

Danger

Hazard Classifications

Acute Tox. 2 Inhalation - Acute Tox. 3 Oral - Acute Tox. 4 Dermal - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Muta. 2 - Repr. 1B - Skin Corr. 1B - Skin Sens. 1 - STOT RE 1 Oral - STOT SE 1 Oral

target_organs

thymus

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk_germany

WGK 3

flash_point_f

235.4 °F - closed cup

flash_point_c

113 °C - closed cup

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

Certificados de análisis (COA)

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Louis P Vera-Portocarrero et al.
Gastroenterology, 135(4), 1369-1378 (2008-08-13)
Sumatriptan is used specifically to relieve headache pain. The possible efficacy of sumatriptan was investigated in 2 models of visceral pain. Pancreatic inflammation was induced by intravenous injection of dibutyltin dichloride. Noninflammatory irritable bowel syndrome was induced by intracolonic instillation
Guoqing Shi et al.
Environmental health perspectives, 117(3), 379-386 (2009-04-02)
Because of the vital importance of the proteasome pathway, chemicals affecting proteasome activity could disrupt essential cellular processes. Although the toxicity of organotins to both invertebrates and vertebrates is well known, the essential cellular target of organotins has not been
Toyoma Kaku et al.
Pancreas, 34(3), 299-309 (2007-04-07)
Chronic pancreatitis consists of excessive leukocyte infiltration and fibrosis. IS-741 has been reported to be an antiinflammatory drug through an inhibitory action on cell adhesion. In this study, we investigated whether IS-741 could inhibit the progression of pancreatic fibrosis through
Kent J Fanning et al.
Antimicrobial agents and chemotherapy, 55(6), 3008-3011 (2011-03-16)
This work sought to define how pancreatitis affected antibiotic distribution in a perfused rat pancreas model. The distribution kinetics of four antibiotics were examined in control animals and animals with pancreatitis. Meropenem and piperacillin distributed into the extracellular space, and
Gisela Sparmann et al.
Cell research, 20(3), 288-298 (2010-01-27)
Origin and fate of pancreatic stellate cells (PSCs) before, during and after pancreatic injury are a matter of debate. The crucial role of PSCs in the pathogenesis of pancreatic fibrosis is generally accepted. However, the turnover of the cells remains
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