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Sigma-Aldrich

Gold nanoparticles

10 nm diameter, OD 1, stabilized suspension in citrate buffer

Synonym(s):

Au NP, Gold Colloid

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About This Item

MDL number:
MFCD00003436
UNSPSC Code:
12352302
PubChem Substance ID:
329765542
NACRES:
NA.23
Pricing and availability is not currently available.

Quality Level

100

form

nanoparticles
suspension

contains

Proprietary Surfactant as stabilizer

concentration

~6.0E+12 particles/mL

OD

1

diameter

10 nm

λmax

515-519 nm

PDI

<0.2

storage temp.

2-8°C

SMILES string

[Au]

InChI

1S/Au

InChI key

PCHJSUWPFVWCPO-UHFFFAOYSA-N

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General description

Gold nanoparticles (AuNPs) are quasi-dynamic materials which are commercially used for various biomedical, electrochemical and energy based applications.[1][2][3][4] AuNPs are highly stable with properties like high surface to volume ratio, high conductivity,[1] and low toxicity.[5]

Application

AuNPs can be potentially used in:
  • biomedical applications as a drug releasing agents[2]
  • cancer radiotherapy due to their excellent surface chemistry and biocompatibility[6][7]
  • electrochemical bio-sensing systems[3]

Ideal for adsorption of thiolated ligands such as oligonucleotides and polyethylene glycols. Also, due to the increased stability, these gold nanoparticles are ideal for use in physical and optical applications. Note: This product is not ideal for protein adsorption. For gold nanoparticles suitable for adsorption of proteins and other ligands for conjugate development, please see our gold nanoparticles stabilized in PBS.

This material is highly monodisperse (<12% variability in size and shape), and provides significantly improved surface reactivity. Applications include Surface Enhanced Raman Lables, Sensing/Detection, Biological Targeting, Plasmonics and Electronics.

Legal Information

Product of CytoDiagnostics, Inc.

Storage Class Code

12 - Non Combustible Liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
MKCV7370
MKCV9323
MKCT0413
MKCT2381
MKCR0419

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Gold nanoparticles for physics, chemistry and biology (2017)
Gold nanoparticles for applications in cancer radiotherapy: Mechanisms and recent advancements
Her S, et al.
Advanced Drug Delivery Reviews, 109(6), 84-101 (2017)
Various methods of gold nanoparticles (GNPs) conjugation to antibodies
Jazayeri MH, et al.
Sensing and Bio-Sensing Research, 9(6), 17-22 (2016)
Gold nanoparticles for applications in energy and environment: synthesis and characterization
Chen Y
Rare Metals, 30(1), 116-120 (2011)
Spectroscopic Study of the Interaction of Carboxyl-Modified Gold Nanoparticles with Liposomes of Different Chain Lengths and Controlled Drug Release by Layer-by-Layer Technology
Kanwa N, et al.
The Journal of Physical Chemistry B, 121(50), 11333-11343 (2017)
View All Related Papers

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Sensitivity Lateral Flow Diagnostic Assays

Steven J. Oldenburg, Ph.D. provides an overview of lateral flow diagnostic assays and discusses the use of ultra-bright reporter particles based on the unique optical properties of gold nanoshells that significantly increase the sensitivity of lateral flow immunoassays.

Sensitivity Lateral Flow Diagnostic Assays

Steven J. Oldenburg, Ph.D. provides an overview of lateral flow diagnostic assays and discusses the use of ultra-bright reporter particles based on the unique optical properties of gold nanoshells that significantly increase the sensitivity of lateral flow immunoassays.

Surface-enhanced Solar Energy Conversion Systems

Sustainable energy sources with high production efficiency are crucial for meeting increasing energy demand.

Sensitivity Lateral Flow Diagnostic Assays

Steven J. Oldenburg, Ph.D. provides an overview of lateral flow diagnostic assays and discusses the use of ultra-bright reporter particles based on the unique optical properties of gold nanoshells that significantly increase the sensitivity of lateral flow immunoassays.

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Questions

1–10 of 18 Questions  

  1. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  2. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

      Helpful?

  3. How to calculate molarity of this Aunps solution?

    1 answer

    1. The molar concentration is 9.93E-09 M. This can be calculated using the weight concentration of 6.07E-02 and the molar mass of 6.11E+06.

      Helpful?

  4. Hello,  I want to know if I can add CTAB (cétyltriméthylammonium bromide) to this solution and expect efficient adsorption with the AuNPs without interference with the already present stabilizer ? Thanks in advance 

    1 answer

    1. There have not been previous attempts on adsorption of non-thiolated ligands to the surfactant stabilized gold nanoparticles. It is difficult to say to what extent the surfactant may influence the adsorption of CTAB to the particles.

      Please test this by transferring 1 mL of gold nanoparticle suspension into a 1.5 mL centrifuge tube, centrifuge it at 17000 x g for 25-30 minutes, remove the supernatant, and resuspend the particles in a solution of water and CTAB (<1% v/v). If the sample appears to aggregate, then this will be a sign that the reagent is not compatible with the particles.

      Helpful?

  5. at which concentration is the citrate buffer?

    1 answer

    1. This is a product of CytoDiagnostics, Inc. It is supplied in 0.1mg/ml citrate buffer supplemented with a proprietary stabilizing solution.

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  6. Is autoclave distilled water okay to use to dilute gold nanoparticle?

    1 answer

    1. Autoclaved, distilled water is suitable to use as a diluent for gold nanoparticles.

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  7. What diluent should be used to dilute gold nanoparticle?

    1 answer

    1. This product is prepared as a susupension in a citrate buffer. It can be further diluted with water. Avoid diluting further with buffers containing other electrolyte salts such as sodium chloride. Due to the gold nanoparticle surface charge, aggregation and color changes will occur.

      Helpful?

  8. Do I need to wash my gold nanoparticles?

    1 answer

    1. For most applications, our gold nanoparticles can be used without any additional washing steps. If you have a sensitive application that requires additional washing the best way to do so is by either centrifugation or filtration.

      Helpful?

  9. How do you attach gold nanoparticles to peptides and peptide conjugates?

    1 answer

    1. To view information on how to attach gold nanoparticles to peptides and peptide conjugates, please view the information in the reference - Rosenthal, S. J. and Wright, D. W. (Eds.). (2005), p. 91-92. NanoBiotechnology Protocols. New Jersey. Humana Press.

      Helpful?

  10. What is the shape of the gold nanoparticles?

    1 answer

    1. The majority (>95%) of the gold nanoparticles are spherical.

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1–10 of 18 Questions  

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