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C646

Name: C646
Brand: SIGMA

≥98% (HPLC), p300/CBP histone acetyltransferase inhibitor, powder

Synonym(s):

4-[4-[[5-(4,5-Dimethyl-2-nitrophenyl)-2-furanyl]methylene]-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl]benzoic acid

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About This Item

Empirical Formula (Hill Notation):

C₂₄H₁₉N₃O₆

CAS Number:

328968-36-1

Molecular Weight:

445.42

UNSPSC Code:

12352200

PubChem Substance ID:

329825079

NACRES:

NA.77

MDL number:

MFCD01784780

Assay:

≥98% (HPLC)

Form:

powder

Storage condition:

desiccated

Pricing and availability is not currently available.

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Properties

Product Name

C646, ≥98% (HPLC)

Quality Segment

100

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

red to brown

solubility

DMSO: >25 mg/mL

storage temp.

2-8°C

SMILES string

Cc1cc(-c2ccc(\C=C3\C(C)=NN(c4ccc(cc4)C(O)=O)C3=O)o2)c(cc1C)[N+]([O-])=O

InChI

1S/C24H19N3O6/c1-13-10-20(21(27(31)32)11-14(13)2)22-9-8-18(33-22)12-19-15(3)25-26(23(19)28)17-6-4-16(5-7-17)24(29)30/h4-12H,1-3H3,(H,29,30)/b19-12-

InChI key

HEKJYZZSCQBJGB-UNOMPAQXSA-N

Description

Application

C646 was used to study the role of p300 in chronic neuropathic pain in rats with chronic constriction injury.

Biochem/physiol Actions

C646 is a competitive histone acetyltransferase (HAT) p300/CBP inhibitor with a Ki of 400 nM and is selective versus other acetyltransferases.

C646 is a potent, competitive, and selective histone acetyltransferase (HAT) p300/CBP inhibitor.

C646 is a potent, cell permeable and selective inhibitor of p300 and CBP (p300/CBP) histone acetyltransferases. Inhibition of p300/CBP by C646 affects the activity of a variety of transcriptional factors such as NF-κB, p53 and MyoD that are associated with physiology, disease processes, hippocampal synaptic plasticity, spatial memory and contextual fear.

Features and Benefits

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

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This Item	382113
Sigma-Aldrich SML0002 C646	Sigma-Aldrich 382113 Histone Acetyltransferase p300 Inhibitor, C646
description ≥98% (HPLC)	description Histone Acetyltransferase p300 Inhibitor, C646, CAS 328968-36-1, is a cell-permeable, reversible inhibitor of p300/CBP HAT (Ki = 400 nM). Competes with acetyl-CoA for the p300 Lys-CoA binding pocket.
form powder	form solid
assay ≥98% (HPLC)	assay ≥99% (sum of isomers, HPLC)
Quality Level 100	Quality Level 100
storage temp. 2-8°C	storage temp. −20°C
solubility DMSO: >25 mg/mL	solubility DMSO: 50 mg/mL
storage condition desiccated	storage condition protect from light, OK to freeze

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Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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