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SAB5702298

Sigma-Aldrich

Anti-nNOS Antibody, clone 5K9R2, Rabbit Monoclonal

Synonym(s):

NOS1, IHPS1, N-NOS, NC-NOS, NOS, bNOS, nNOS, nitric oxide synthase 1

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.46

Pricing and availability is not currently available.

biological source

rabbit

Quality Level

material

colorless

clone

5K9R2, monoclonal

form

liquid

mol wt

160 kDa

species reactivity

rat, rat, human

concentration

3 mg/mL

technique(s)

immunofluorescence: 1:50 - 1:200
western blot: 1:500 - 1:2000

color

colorless

General description

The protein encoded by this gene belongs to the family of nitric oxide synthases, which synthesize nitric oxide from L-arginine. Nitric oxide is a reactive free radical, which acts as a biologic mediator in several processes, including neurotransmission, and antimicrobial and antitumoral activities. In the brain and peripheral nervous system, nitric oxide displays many properties of a neurotransmitter, and has been implicated in neurotoxicity associated with stroke and neurodegenerative diseases, neural regulation of smooth muscle, including peristalsis, and penile erection. This protein is ubiquitously expressed, with high level of expression in skeletal muscle. Multiple transcript variants that differ in the 5′ UTR have been described for this gene but the full-length nature of these transcripts is not known. Additionally, alternatively spliced transcript variants encoding different isoforms (some testis-specific) have been found for this gene.

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 1335-1434 of human nNOS (P29475).
PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.

Application

WB, IF/ICC

Storage Class Code

10 - Combustible liquids

WGK

WGK 1


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