S8195

Swainsonine

from Metarrhizium anisopliae, ≥98% (TLC)

• Synonym(s): (1S,2R,8R,8aR)-1,2,8-Octahydroindolizidinetriol
• Empirical Formula (Hill Notation): C₈H₁₅NO₃
• CAS Number: 72741-87-8
• Molecular Weight: 173.21
• UNSPSC Code: 51102829
• NACRES: NA.85
• PubChem Substance ID: 24899779
• MDL number: MFCD00017554
• Beilstein/REAXYS Number: 4175740

Properties

• biological source: Metarrhizium anisopliae
• Quality Segment: 200
• assay: ≥98% (TLC)
• form: lyophilized powder
• storage condition: (Keep container tightly closed in a dry and well-ventilated place.)
• color: white to faint yellow
• solubility: H₂O: soluble 1 mg/mL
• antibiotic activity spectrum: neoplastics
• mode of action: enzyme | inhibits
• storage temp.: 2-8°C
• SMILES string: O[C@@H]1CCCN2C[C@@H](O)[C@@H](O)C12
• InChI: 1S/C8H15NO3/c10-5-2-1-3-9-4-6(11)8(12)7(5)9/h5-8,10-12H,1-4H2/t5-,6-,7?,8-/m1/s1
• InChI key: FXUAIOOAOAVCGD-DCDLSZRSSA-N

Description

Application

Swainsonine is a potent inhibitor of various α-mannosidases, especially of α-mannosidase II. It inhibits glycoprotein processing and also acts as immune modulator.

Swainsonine is an indolizidine alkaloid from the plant Metarrhizium anisopliae that is used as a potent α-mannosidase inhibitor. Product S8195 has been used in chemical inhibition assays of CHO Lec2 cells to inhibit glycosylation .

Biochem/physiol Actions

Swainsonine is a potent α-mannosidase inhibitor. It also has antimetastatic, antiproliferative, and immunomodulatory activity . It also inhibits glycoprotein processing.

Packaging

1MG

Preparation Note

Soluble in water, methanol, DMSO

Other Notes

Keep container tightly closed in a dry and well-ventilated place.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• ppe: dust mask type N95 (US), Eyeshields, Gloves