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P8477

Sigma-Aldrich

Picotamide

Synonym(s):

4-Methoxy-N,N′-bis(3-pyridinylmethyl)-1,3-benzenedicarboxamide

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About This Item

Empirical Formula (Hill Notation):
C21H20N4O3
CAS Number:
32828-81-2
Molecular Weight:
376.41
EC Number:
251-245-7
MDL number:
MFCD00866792
UNSPSC Code:
12352204
PubChem Substance ID:
24278656
NACRES:
NA.83

Assay

≥98%

form

powder

solubility

ethanol: 50 mg/mL, clear, colorless to light yellow

SMILES string

COc1ccc(cc1C(=O)NCc2cccnc2)C(=O)NCc3cccnc3

InChI

1S/C21H20N4O3/c1-28-19-7-6-17(20(26)24-13-15-4-2-8-22-11-15)10-18(19)21(27)25-14-16-5-3-9-23-12-16/h2-12H,13-14H2,1H3,(H,24,26)(H,25,27)

InChI key

KYWCWBXGRWWINE-UHFFFAOYSA-N

Gene Information

human ... TBXA2R(6915)

Biochem/physiol Actions

Eicosenoid receptor antagonist; a thromboxane A2 antagonist; antiplatelet agent.

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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P A Modesti et al.
European journal of pharmacology, 169(1), 85-93 (1989-10-04)
On the basis of indirect pharmacological evidence, picotamide, a methoxy derivative of 4-hydroxy-isophthalic acid (N,N'bis(3-picolyl)-4-methoxy-isophthalamide) has been postulated to inhibit platelet aggregation by competitively interfering with the thromboxane A2 (TxA2) platelet receptor. In the present study the interaction between picotamide
A Giustina et al.
Diabetes, 47(3), 423-430 (1998-03-31)
Picotamide both inhibits thromboxane synthetase and acts as a thromboxane antagonist at the receptor level. We investigated the long-term effect of picotamide on urinary albumin excretion (UAE) at rest and induced by exercise in 30 type 2 diabetic patients who
G Bettinetti et al.
Journal of pharmaceutical sciences, 88(11), 1133-1139 (1999-11-17)
Picotamide is an antiplatelet agent given by mouth as monohydrate (PICOW) (Plactidil) in thrombo-embolic disorders. This study deals with physical characterization of PICOW recrystallized from various solvents and the respective dehydration products using X-ray powder diffractometry (XRD), infrared spectroscopy (IR)
M Y Abeywardena et al.
Prostaglandins, leukotrienes, and essential fatty acids, 65(2), 91-97 (2001-09-08)
Two currently available edible oils-olive and canola-and two oil blends of plant origin having different n-3/n-6 polyunsaturated fatty acid (PUFA) ratios were evaluated for their ability to modify vascular dysfunction in the spontaneously hypertensive rat (SHR). Synthetic diets supplemented with
Carola Buccellati et al.
European journal of pharmacology, 443(1-3), 133-141 (2002-06-05)
We evaluated the capacity of anti-aggregating agents to influence thromboxane A(2) and prostacyclin formation, arachidonic acid-endoperoxide redirection, platelet aggregation and vessel tone, in isolated rabbit aorta incubated with homologous platelets. Picotamide (N,N'bis(3-pyridinylmethyl)-4-methoxy-isophthalamide), the only dual thromboxane A(2)-synthase inhibitor/receptor antagonist in
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