Peanut lectin is not a glycoprotein. Although peanut lectin binds specifically to a particular carbohydrate (beta-gal(1-->3)galNac) in other molecules, the lectin itself does not contain any carbohydrate. Please see page 231 of the following paper: R. Banerjee, et al., "Crystal structure of peanut lectin, a protein with an unusual quaternary structure". Proc. Nat. Acad. Sci., USA, 91, 227-231 (1994).
L0881
Lectin from Arachis hypogaea (peanut)
lyophilized powder, Affinity-purified
Synonym(s):
PNA, Peanut agglutinin
Sign Into View Organizational & Contract Pricing
All Photos(2)
About This Item
UNSPSC Code:
12352202
NACRES:
NA.32
Pricing and availability is not currently available.
Recommended Products
form
lyophilized powder
Quality Level
potency
<0.1 μg per mL agglutination activity
quality
Affinity-purified
impurities
salt, free
storage temp.
−20°C
Looking for similar products? Visit Product Comparison Guide
General description
Lectin from Arachis hypogaea (peanut) is a homotetrameric protein of 110 kDa.[1]
Application
Biochem/physiol Actions
Lectin from Arachis hypogaea (peanut) possess specificity towards β -D-Gal(1-3)-D-galNAc residue of Thomson − Friedenreich antigen.[5][1] It is the most widely used diagnostic and prognostic marker for many squamous cell carcinomas.[5]
PNA does not agglutinate normal human erythrocytes, but strongly agglutinates neuraminidase treated erythrocytes. PNA has potent anti-T activity similar to the anti-T antibody in human sera. The lectin can be used to distinguish between human lymphocyte subsets.
Analysis Note
Agglutination activity is expressed in μg/ml and is determined from serial dilutions in phosphate buffered saline, pH 6.8, of a 1 mg/ml solution. This activity is the lowest concentration to agglutinate a 2% suspension of neuraminidase treated human blood group O erythrocytes after 1 hr incubation at 25 °C.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Choose from one of the most recent versions:
Certificates of Analysis (COA)
Lot/Batch Number
Don't see the Right Version?
If you require a particular version, you can look up a specific certificate by the Lot or Batch number.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Customers Also Viewed
In vivo tumor cell adhesion in the pulmonary microvasculature is exclusively mediated by tumor cell-endothelial cell interaction
Gassmann P
BMC Cancer, 10(1), 177-177 (2010)
In vitro and in vivo antitumor effects of Peanut agglutinin through induction of apoptotic and autophagic cell death
Mukhopadhyay S, et al.
Food And Chemical Toxicology, 64, 369-377 (2014)
Lectin binding and effects in culture on human cancer and non-cancer cell lines: examination of issues of interest in drug design strategies
Petrossian K, et al.
Acta Histochemica, 109(6), 491-500 (2007)
Alejandro J Cagnoni et al.
Acta crystallographica. Section D, Structural biology, 76(Pt 11), 1080-1091 (2020-11-03)
Carbohydrate-lectin interactions are involved in important cellular recognition processes, including viral and bacterial infections, inflammation and tumor metastasis. Hence, structural studies of lectin-synthetic glycan complexes are essential for understanding lectin-recognition processes and for the further design of promising chemotherapeutics that
Adhesion of plant roots to poly-L-lysine coated polypropylene substrates
Towler MJ and Weathers PJ
Journal of Biotechnology, 101(2), 147-155 (2003)
-
Is the peanut lectin (Lectin from Arachis hypogaea) a glycoprotein? If so, what is the carbohydrate content?
1 answer-
Helpful?
-
-
What is the Department of Transportation shipping information for this product?
1 answer-
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
Helpful?
-
-
How does the storage temperature relate to shipping conditions?
1 answer-
The storage conditions that a Sigma-Aldrich catalog and label recommend for products are deliberately conservative. For many products, long-term storage at low temperatures will increase the time during which they are expected to remain in specification and therefore are labeled accordingly. Where short-term storage, shipping time frame, or exposure to conditions other than those recommended for long-term storage will not affect product quality, Sigma-Aldrich will ship at ambient temperature. The products sensitive to short-term exposure to conditions other than their recommended long-term storage are shipped on wet or dry ice. Ambient temperature shipping helps to control shipping costs for our customers. At any time, our customers can request wet- or dry-ice shipment, but the special handling is at customer expense if our product history indicates that the product is stable for regular shipment.
Helpful?
-
Active Filters
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service
