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Domperidone

Name: Domperidone
Brand: SIGMA

≥98% (HPLC), Dopamine D2 receptor antagonist, powder

Synonym(s):

4-(5-Chloro-2-oxo-1-benzimidazolinyl)-1-[3-(2-oxobenzimidazolinyl)propyl]piperidine

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About This Item

Empirical Formula (Hill Notation):

C₂₂H₂₄ClN₅O₂

CAS Number:

57808-66-9

Molecular Weight:

425.91

NACRES:

NA.77

PubChem Substance ID:

24277911

UNSPSC Code:

12352200

EC Number:

260-968-7

MDL number:

MFCD00069256

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

Pricing and availability is not currently available.

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Properties

Product Name

Domperidone, powder, ≥98% (HPLC)

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white

solubility

DMSO: >10 mg/mL, 0.1 M HCl: soluble, 0.1 M NaOH: slightly soluble, H₂O: insoluble

originator

Johnson & Johnson

SMILES string

Clc1ccc2N(C3CCN(CCCN4C(=O)Nc5ccccc45)CC3)C(=O)Nc2c1

InChI

1S/C22H24ClN5O2/c23-15-6-7-20-18(14-15)25-22(30)28(20)16-8-12-26(13-9-16)10-3-11-27-19-5-2-1-4-17(19)24-21(27)29/h1-2,4-7,14,16H,3,8-13H2,(H,24,29)(H,25,30)

InChI key

FGXWKSZFVQUSTL-UHFFFAOYSA-N

Gene Information

human ... DRD1(1812), DRD2(1813), DRD3(1814), DRD4(1815), DRD5(1816), KCNH2(3757)
rat ... Drd1a(24316), Drd2(24318), Drd3(29238), Htr3a(79246)

Description

Biochem/physiol Actions

Peripheral dopamine receptor antagonist that does not cross the blood-brain barrier; anti-emetic.

Features and Benefits

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

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This Item	H3041	D129	E101
Sigma-Aldrich D122 Domperidone	Sigma-Aldrich H3041 Halopemide	Sigma-Aldrich D129 R-(+)-DIOA	Sigma-Aldrich E101 S-(−)-Eticlopride hydrochloride
assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)
form powder	form powder	form solid	form powder
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
solubility DMSO: >10 mg/mL, 0.1 M NaOH: slightly soluble, 0.1 M HCl: soluble, H₂O: insoluble	solubility DMSO: >10 mg/mL	solubility H₂O: insoluble <0.11 mg/mL, DMSO: >20 mg/mL, 0.1 M HCl: insoluble, 0.1 M NaOH: soluble, ethanol: soluble	solubility H₂O: soluble >10 mg/mL, ethanol: soluble 2.6 mg/mL, 0.1 M HCl: soluble 7 mg/mL
originator Johnson & Johnson	originator -	originator -	originator -
color white	color off-white	color white	color off-white

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pictograms

GHS08

signalword

Warning

hcodes

H361fd

pcodes

P201 - P202 - P280 - P308 + P313 - P405 - P501

Hazard Classifications

Repr. 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

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Certificates of Analysis (COA)

Lot/Batch Number

0000353517

0000523132

0000523134

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Domperidone, a specific in vitro dopamine antagonist, devoid of in vivo central dopaminergic activity.

P M Laduron et al.

Biochemical pharmacology, 28(14), 2161-2165 (1979-07-15)

Domperidone. A review of its pharmacological activity, pharmacokinetics and therapeutic efficacy in the symptomatic treatment of chronic dyspepsia and as an antiemetic.

R N Brogden et al.

Drugs, 24(5), 360-400 (1982-11-01)

Domperidone is a dopamine antagonist that does not readily enter the central nervous system. Given parenterally or orally it increases gastric emptying of liquids and increases lower oesophageal sphincter pressure in healthy subjects. The antiemetic and pharmacodynamic profile of domperidone

Domperidone: review of pharmacology and clinical applications in gastroenterology.

Savio C Reddymasu et al.

The American journal of gastroenterology, 102(9), 2036-2045 (2007-05-10)

Domperidone is a dopamine-2 receptor antagonist. It acts as an antiemetic and a prokinetic agent through its effects on the chemoreceptor trigger zone and motor function of the stomach and small intestine. Unlike metoclopramide, it does not cause any adverse

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Global Trade Item Number

SKU	GTIN
D122-25MG	04061833559000
D122-500MG	04061833559017
D122-100MG	04061833558997

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