B4056
Bisindolylmaleimide XI hydrochloride
≥98% (TLC), solid
Synonym(s):
Ro 32-0432
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About This Item
Empirical Formula (Hill Notation):
C28H28N4O2 · HCl
Molecular Weight:
489.01
MDL number:
UNSPSC Code:
12352111
PubChem Substance ID:
NACRES:
NA.77
Recommended Products
Quality Level
Assay
≥98% (TLC)
form
solid
solubility
DMSO: soluble
storage temp.
−20°C
SMILES string
Cl.CN(C)CC1CCn2c(C1)cc3ccc(cc23)C4=C(C(=O)NC4=O)c5cn(C)c6ccccc56
InChI
1S/C28H28N4O2.ClH/c1-30(2)15-17-10-11-32-20(12-17)13-18-8-9-19(14-24(18)32)25-26(28(34)29-27(25)33)22-16-31(3)23-7-5-4-6-21(22)23;/h4-9,13-14,16-17H,10-12,15H2,1-3H3,(H,29,33,34);1H
InChI key
WMVQGKBSNAIMHI-UHFFFAOYSA-N
Biochem/physiol Actions
Selective inhibitor of protein kinase C.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Guillaume Robert et al.
PloS one, 4(11), e7889-e7889 (2009-11-20)
CML is an hematopoietic stem cell disease characterized by the t(9;22) (q34;q11) translocation encoding the oncoprotein p210BCR-ABL. The effect of acadesine (AICAR, 5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside) a compound with known antileukemic effect on B cell chronic lymphoblastic leukemia (B-CLL) was investigated in different
Florence P Varodayan et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 37(17), 4593-4603 (2017-04-02)
L-type voltage-gated calcium channels (LTCCs) are implicated in several psychiatric disorders that are comorbid with alcoholism and involve amygdala dysfunction. Within the amygdala, the central nucleus (CeA) is critical in acute alcohol's reinforcing actions, and its dysregulation in human alcoholics
M Signore et al.
Cell death & disease, 5, e1223-e1223 (2014-05-09)
Glioblastoma (GBM) is the most common and deadly adult brain tumor. Despite aggressive surgery, radiation, and chemotherapy, the life expectancy of patients diagnosed with GBM is ∼14 months. The extremely aggressive nature of GBM results from glioblastoma stem-like cells (GSCs)
S Khom et al.
Science advances, 6(12), eaaz1050-eaaz1050 (2020-03-25)
Behavioral and clinical studies suggest a critical role of substance P (SP)/neurokinin-1 receptor (NK-1R) signaling in alcohol dependence. Here, we examined regulation of GABA transmission in the medial subdivision of the central amygdala (CeM) by the SP/NK-1R system, and its
Thitima Kasemsuk et al.
Journal of immunotoxicology, 17(1), 186-193 (2020-10-20)
Cadmium (Cd) is accumulated in human astrocytes and induces the production of interleukin (IL)-6 and IL-8. Astrocytes are one of the major sources of chemokine C-C motif ligand 2 (CCL2; known as monocyte chemoattractant protein-1 [MCP-1]), in the brain. Elevated
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