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380R-1

Sigma-Aldrich

Arginase-1 (SP156) Rabbit Monoclonal Antibody

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About This Item

UNSPSC Code:
12352204
NACRES:
NA.41

biological source

rabbit

Quality Level

100
500

conjugate

unconjugated

antibody form

culture supernatant

antibody product type

primary antibodies

clone

SP156, monoclonal

description

For In Vitro Diagnostic Use in Select Regions (See Chart)

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL concentrate (380R-14)
vial of 0.5 mL concentrate (380R-15)
bottle of 1.0 mL predilute (380R-17)
vial of 1.0 mL concentrate (380R-16)
bottle of 7.0 mL predilute (380R-18)

manufacturer/tradename

Cell Marque™

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100

isotype

IgG

control

hepatocellular carcinoma, normal liver

shipped in

wet ice

storage temp.

2-8°C

visualization

cytoplasmic, nuclear

Gene Information

human ... ARG1(383)

General description

Arginase is a key metalloenzyme of the urea cycle responsible for the hydrolysis of L-arginine to L-ornithine and urea. Two main isoforms exist, arginase-1 and arginase-2, encoded by different genes and with different tissue distributions. The arginase-1 isoform is a cytosolic protein that is produced by normal liver tissue and is typically expressed in hepatocellular carcinoma. Arginase-1 (SP156) is used as an immunohistochemical marker to aid in the identification of hepatocellular carcinoma.

Quality


IVD
IVD
IVD
RUO

Linkage

Arginase-1 Positive Control Slides, Product No. 380S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Preparation Note

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Legal Information

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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H B el-Serag
Clinics in liver disease, 5(1), 87-107 (2001-02-24)
The epidemiology of hepatocellular carcinoma (HCC) is characterized by marked differences between genders, ethnic groups, and geographic regions. These variations are explained by the nature, frequency, and time of acquisition of the major risk factors for cirrhosis--namely hepatitis B virus
Benign and malignant tumors of the liver
Linda DF
Surgical Pathology of the GI Tract, Liver, Biliary Tract, and Pancreas, 2nd ed., 1291-1325 (2009)
A Wee
Cytopathology : official journal of the British Society for Clinical Cytology, 22(5), 287-305 (2011-07-19)
The role of fine needle aspiration (FNA) biopsy of the liver has evolved. Advances in imaging modalities have obviated the need for tissue confirmation in clinically classic hepatocellular carcinoma (HCC). The risks of needle tract seeding and haematogenous dissemination have
Alexandre Sherlley Casimiro Onofre et al.
Cancer, 111(4), 259-268 (2007-06-15)
Difficulties with cytologic diagnoses on fine-needle aspiration cytology (FNAC) of the liver can be overcome by the application of immunocytochemical panels applied on smears. The aim of the current study was to analyze the performance of a panel of monoclonal
T H Niemann et al.
Cancer, 87(5), 295-298 (1999-10-28)
Fine-needle aspiration biopsy (FNAB) is frequently used to diagnose mass lesions in the liver. Differentiating metastatic adenocarcinoma from primary hepatocellular carcinoma can be difficult. Despite a number of morphologic criteria, there remain occasional cases in which the cytologic features fail
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