B1000000

Betamethasone

European Pharmacopoeia (EP) Reference Standard

• Synonym(s): 9α-Fluoro-11β,17α,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione, 9α-Fluoro-16β-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione, 9α-Fluoro-16β-methylprednisolone
• Empirical Formula (Hill Notation): C₂₂H₂₉FO₅
• CAS Number: 378-44-9
• Molecular Weight: 392.46
• MDL number: MFCD00062969
• UNSPSC Code: 41116107
• PubChem Substance ID: 329773150
• NACRES: NA.24

Properties

• biological source: synthetic
• grade: pharmaceutical primary standard
• Agency: EP
• API family: betamethasone
• packaging: pkg of 60 mg
• manufacturer/tradename: EDQM
• storage condition: protect from light
• color: white
• mp: 235-237 °C (lit.); 235.6 °C (456.1°F at 1013.0 hPa)
• solubility: water: slightly soluble 0.063 g/L at 37 °C
• density: 0.305 g/cm³ at 25 °C (77°F)
• application(s): pharmaceutical (small molecule)
• format: neat
• shipped in: ambient
• storage temp.: 2-8°C
• SMILES string: [H][C@@]12C[C@H](C)[C@](O)(C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]3(F)[C@@]2([H])CCC4=CC(=O)C=C[C@]34C
• InChI: 1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15-,16-,17-,19-,20-,21-,22-/m0/s1
• InChI key: UREBDLICKHMUKA-DVTGEIKXSA-N
• Gene Information: human ... NR3C1(2908)

Description

General description

Betamethasone, a synthetic glucocorticoid, belongs to the corticosteroid family of active pharmaceutical ingredients (APIs).

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Betamethasone EP reference standard may be used as a pharmaceutical primary standard for the determination of the analyte in pharmaceutical formulations by chromatographic and spectrophotometric techniques.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

Safety Information

• Pictograms: GHS08
• Signal Word: Danger
• Hazard Statements: H360FD,H373
• Precautionary Statements: P202 - P260 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Repr. 1B - STOT RE 2
• Target Organs: Liver,Kidney,Endocrine system
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 2
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable