M-007

(±)-Methadone solution

1 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant^®

• Empirical Formula (Hill Notation): C₂₁H₂₇NO
• CAS Number: 76-99-3
• Molecular Weight: 309.45
• EC Number: 200-659-6
• MDL number: MFCD00056289
• UNSPSC Code: 41116107
• PubChem Substance ID: 329817685
• NACRES: NA.24

Properties

• grade: certified reference material
• form: liquid
• packaging: ampule of 1 mL
• manufacturer/tradename: Cerilliant^®
• drug control: Narcotic Licence Schedule A (Switzerland); estupefaciente (Spain); Decreto Lei 15/93: Tabela IA (Portugal)
• concentration: 1 mg/mL in methanol
• technique(s): gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• application(s): forensics and toxicology
• format: single component solution
• storage temp.: −20°C
• SMILES string: CCC(C(CC(C)N(C)C)(C1=CC=CC=C1)C2=CC=CC=C2)=O
• InChI: 1S/C21H27NO/c1-5-20(23)21(16-17(2)22(3)4,18-12-8-6-9-13-18)19-14-10-7-11-15-19/h6-15,17H,5,16H2,1-4H3
• InChI key: USSIQXCVUWKGNF-UHFFFAOYSA-N
• Gene Information: human ... OPRM1(4988)

Description

General description

Methadone is a synthetic opioid used medically as an analgesic and as a maintenance anti-addictive for use in patients with opioid dependency. The drug is sold under several trade names such as Symoron, Dolophine^®, Amidone, Methadose^®, Physeptone, or Heptadon. This Certified Spiking Solution^® is suitable for LC/MS or GC/MS testing methods in pain prescription monitoring, forensic analysis or clinical toxicology.

Application

• Neurobehavioral and Molecular Changes in a Rodent Model: This study leverages Imipramine hydrochloride in a rodent model to investigate ACTH-induced HPA axis dysfunction, focusing on its effects on neurobehavior and molecular signaling pathways. This research underscores the utility of Imipramine hydrochloride in studying stress-related neuropsychiatric disorders, enhancing understanding of its therapeutic mechanisms in clinical settings (Sallie et al., 2024).


• Electrochemical DNA Biosensor Development: Imipramine hydrochloride is used in the development of novel electrochemical DNA biosensors, highlighting its role in enhancing the sensitivity and specificity of genetic analysis. This application is pivotal in biotechnological advancements for genomics and personalized medicine (Augustín et al., 2024).


• Diabetic Peripheral Neuropathy: Prevention and Treatment: Research incorporating Imipramine hydrochloride focuses on its effectiveness in managing symptoms of diabetic peripheral neuropathy, providing insights into its analgesic properties and mechanisms of action in nerve pain management, which is crucial for developing better therapeutic strategies (Bragg et al., 2024).


• Microvesicle Particles in Burn Injury: Utilizes Imipramine hydrochloride in a study investigating the role of microvesicle particles in mediating damage in burn injury cases, offering a new perspective on the systemic impacts of burn injuries and the potential interventions to mitigate these effects (Lohade et al., 2024).


• Sustainable Biosensor for Tricyclic Antidepressants: Highlights the use of Imipramine hydrochloride in the development of sustainable beeswax modified cellulose paper for the detection of tricyclic antidepressants in biofluids. This innovative approach represents a significant step forward in environmental sustainability and drug monitoring technologies (González-Bermúdez et al., 2024).

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation

Dolophine is a registered trademark of Roxane Laboratories, Inc.

Methadose is a registered trademark of Mallinckrodt Inc.

Safety Information

• Pictograms: GHS02,GHS06,GHS08
• Signal Word: Danger
• Hazard Statements: H225,H301 + H311 + H331,H370
• Precautionary Statements: P210 - P280 - P301 + P310 + P330 - P302 + P352 + P312 - P304 + P340 + P311
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
• Target Organs: Eyes
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 2
• Flash Point(F): 49.5 °F - closed cup
• Flash Point(C): 9.7 °C - closed cup