465089

3,4-Difluorophenylboronic acid

≥95%

• Synonym(s): 3,4-Difluorobenzeneboronic acid
• Linear Formula: F₂C₆H₃B(OH)₂
• CAS Number: 168267-41-2
• Molecular Weight: 157.91
• MDL number: MFCD00807405
• UNSPSC Code: 12352103
• PubChem Substance ID: 24870244
• NACRES: NA.22

Properties

• Assay: ≥95%
• mp: 305-310 °C (lit.)
• SMILES string: OB(O)c1ccc(F)c(F)c1
• InChI: 1S/C6H5BF2O2/c8-5-2-1-4(7(10)11)3-6(5)9/h1-3,10-11H
• InChI key: RMGYQBHKEWWTOY-UHFFFAOYSA-N

Description

Application

3,4-Difluorophenylboronic acid can be used as a reactant to prepare:

• Fluorinated biaryl derivatives via Suzuki cross-coupling reaction with aryl and heteroaryl halides.
• Flurodiarylmethanols by reacting with aryl aldehydes using Ni catalyst.
• Conjugated fluorodiazaborinines by treating with diamines via intermolecular dehydration reaction for the detection of explosives.

Reactant involved in:

• Suzuki cross-coupling reactions with aryl and heteroaryl halides
• Oxo directing Liebeskind-Srogl cross-coupling reactions with gem-dihaloolefin-type α-oxo ketene dithioacetals
• Substitution reactions with enyne acetates and carbonates

Other Notes

Contains varying amounts of anhydride

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves