301485
1-Chloroethyl chloroformate
98%
Synonym(s):
ACE-Cl
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About This Item
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vapor pressure
3.25 psi ( 20 °C)
Quality Level
Assay
98%
form
liquid
refractive index
n20/D 1.422 (lit.)
bp
118-119 °C (lit.)
density
1.325 g/mL at 25 °C (lit.)
functional group
chloro
storage temp.
2-8°C
SMILES string
CC(Cl)OC(Cl)=O
InChI
1S/C3H4Cl2O2/c1-2(4)7-3(5)6/h2H,1H3
InChI key
QOPVNWQGBQYBBP-UHFFFAOYSA-N
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General description
1-Chloroethyl chloroformate is used as a selective dealkylating agent for tertiary amines.
Application
1-Chloroethyl chloroformate was used:
- for N-demethylation reaction during determination of multiple drugs of abuse in biological fluids using capillary electrophoresis with native fluorescence and laser-induced fluorescence detection
- as catalyst in chemoselective desilylation of silyl-protected alcohols
- as reagent in N-demethylation of tertiary amines to produce drug metabolite reference material for forensic toxicological applications
- as reagent to cleave benzhydryl groups from amines
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 2 Inhalation - Acute Tox. 4 Oral - Eye Dam. 1 - Flam. Liq. 3 - Skin Corr. 1B
Storage Class Code
3 - Flammable liquids
WGK
WGK 3
Flash Point(F)
104.9 °F - closed cup
Flash Point(C)
40.5 °C - closed cup
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Preparation of< i> N</i>-demethylated drug metabolites for analytical purposes using 1-chloroethyl chloroformate.
Forensic Science International, 85(3), 193-198 (1997)
Efficient chemoselective deprotection of silyl ethers using catalytic 1-chloroethyl chloroformate in methanol
Tetrahedron, 61(52), 12227-12237 (2005)
Efficient chemoselective deprotection of silyl ethers using catalytic 1-chloroethyl chloroformate in methanol.
Tetrahedron, 61(52), 12227-12237 (2005)
Tetrahedron, 62, 6869-6869 (2006)
Electrophoresis, 25(10-11), 1592-1600 (2004-06-10)
Methods for separation and determination of multiple drugs of abuse in biological fluids using capillary electrophoresis (CE) with native fluorescence and laser-induced fluorescence (LIF) detection are described herein. Using native fluorescence, normorphine, morphine, 6-acetyl morphine (6-AM), and codeine were analyzed
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