T1408
holo-Transferrin bovine
Synonym(s):
Siderophilin, Siderophilin, iron-saturated
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About This Item
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biological source
bovine
Quality Level
Assay
97-100% (agarose gel electrophoresis)
form
powder
technique(s)
cell culture | mammalian: suitable
UniProt accession no.
storage temp.
2-8°C
Gene Information
bovine ... TF(280705)
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General description
Application
Holo-Transferrin bovine has been used:
- as a RPMI-1640 medium supplement for culturing cancer cell lines[3]
- as a component of visceral fat differentiation medium for the pre-adipocytes primary cell culture[4]
- to test the influence of iron-saturation complex on the growth of Malassezia pachydermatis[5]
- as a standard for strong anion exchange (SAX) reactor measurements[6]
Biochem/physiol Actions
Holo-Transferrin (holo-Tf) or the iron bound transferrin functions as an iron sequester and is crucial for defense against microbial infections.[1] Transferrin is used as a model system for understanding the kinetics and dynamics of protein structure based interactions. It is a potential candidate for delivery studies for its ability to cross the blood-brain barrier.[7] The interaction of holo-Tf with thrombin is implicated in the pathogenesis of intracerebral hemorrhage.[8] Polymorphisms in the bovine transferrin gene has led to the generation of 10 variant transferrin protein.[2]
Studies show that treatment of breast cancer cells with holo-transferrin in combination with dihydroartemisinin results in increased tumor cell death due to elevated levels of intracellular ferrous iron. [9]
Analysis Note
Purity by agarose gel electrophoresis.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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