SRP3266
IL-7 human
Animal-component free, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC)
Synonym(s):
Lymphopoietin 1 (LP-1), pre-B cell factor
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About This Item
UNSPSC Code:
12352202
NACRES:
NA.32
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biological source
human
recombinant
expressed in E. coli
Assay
≥98% (HPLC)
≥98% (SDS-PAGE)
form
lyophilized
potency
≤0.5 ng/mL ED50
mol wt
17.4 kDa
packaging
pkg of 10 μg
impurities
<0.1 EU/μg endotoxin, tested
color
white to off-white
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... IL7(3574)
General description
IL7 (interleukin 7) was first identified in 1988 in a bone marrow culture as a factor that facilitated murine B cell precursors growth. It is a cytokine produced by non-lymphoid cells in lymphoid organs. In humans, it is also produced by keratinocytes, peripheral blood dendritic cells,follicular dendritic cells, intestinal epithelial cells, hepatic tissue, endothelial cells, smooth muscle cells and fibroblasts. IL7 gene is localized to human chromosome 8q12-q13. It is a glycoprotein with a four a-helix structure with a hydrophobic core. Recombinant human IL-7 is a 17.4 kDa protein containing 153 amino acid residues.
Biochem/physiol Actions
IL7 (interleukin 7) is crucial for lymphocyte survival and development. It is required for the survival, proliferation and the rearrangement of certain TCR (T cell receptor) genes in earliest thymus stem cells. During later stages, in thymus, it is essential for the positive selection of CD8 cells. IL7 is also essential for the survival and homeostatic proliferation of mature T cells which have left the thymus. In patients undergoing allogeneic haematopoietic stem cell transplantation (HSCT), increased IL-7 plasma levels in the early post-transplant period is linked with suppressed T cell counts and elevated risks of acute graft-versus-host disease (aGVHD) and mortality. IL7 shows varied tear expression levels during different stages of Graves′ ophthalmopathy (GO), and thus, might be implicated in the pathogenesis of GO.
Physical form
Lyophilized from 10 mM Acetic Acid.
Reconstitution
Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/mL. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2
Storage Class Code
10 - Combustible liquids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Interleukin-7 expression in tears and orbital tissues of patients with Graves' ophthalmopathy.
Cai K and Wei R
Endocrine, 44, 140-144 (2013)
Cell biology of IL-7, a key lymphotrophin.
Jiang Q
Cytokine & Growth Factor Reviews, 16, 513-533 (2005)
Edwin Leeansyah et al.
PLoS pathogens, 11(8), e1005072-e1005072 (2015-08-22)
Mucosa-associated invariant T (MAIT) cells represent a large innate-like evolutionarily conserved antimicrobial T-cell subset in humans. MAIT cells recognize microbial riboflavin metabolites from a range of microbes presented by MR1 molecules. MAIT cells are impaired in several chronic diseases including
Fathollah Kalantar et al.
Iranian journal of immunology : IJI, 11(1), 1-12 (2014-03-19)
Type 2 diabetes (T2D) is a chronic metabolic disorder in which beta-cells are destroyed. The islet amyloid polypeptide (IAPP) produced by beta-cells has been reported to influence beta-cell destruction. To evaluate if IAPP can act as an autoantigen and therefore
A E Namen et al.
The Journal of experimental medicine, 167(3), 988-1002 (1988-03-01)
We have used a biological assay system we developed to biochemically purify a previously uncharacterized murine lymphopoietic growth factor designated lymphopoietin 1 (LP-1). This factor is capable of stimulating the proliferation and extended maintenance of precursor cells of the B
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